Document Detail


Impaired baroreflex function in temporal lobe epilepsy.
MedLine Citation:
PMID:  17041741     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Changes of cardiovascular function are frequent in temporal lobe epilepsy (TLE). The baroreflex - the most important reflex for cardiovascular stability - has not been studied systematically in TLE. We evaluated cardiovascular variability and baroreflex function in TLE. In 22 TLE patients and 20 controls, we continuously monitored heart rate (HR) and blood pressure (BP). Time-domain parameters were derived from recordings at rest and from standard cardiovascular reflex tests. Spectral analysis determined sympathetic and parasympathetic modulation of HR and BP in the low (LF-power) and high frequency range (HF-power). We calculated the relative LF- and HF-powers of HR in relation to the sum of LF- and HF-powers. LF/HF-ratio of HR was assessed as a parameter of sympatheticovagal balance. LF-transfer function gain between BP and HR determined baroreflex function.Time-domain parameters did not differ between TLE patients and controls. Spectral analysis showed decreased absolute LF- and HF-powers but increased relative LF-power and LF/HF-ratio of HR in TLE. LF-transfer function gain between BP and HR was reduced in TLE (p<0.05). The reduction of absolute LF- and HF-powers indicates decreased total autonomic variability in TLE. However, increased relative LF-power and LF/HF-ratio of HR in TLE show a relative increase of sympathetic tone. Most importantly, we demonstrate an impaired baroreflex function in TLE. These cardiovascular autonomic abnormalities may contribute to cardiac arrhythmia in TLE.
Authors:
Mathias Dütsch; Max J Hilz; Orrin Devinsky
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-13
Journal Detail:
Title:  Journal of neurology     Volume:  253     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-11-06     Completed Date:  2007-02-26     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1300-8     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany. max.hilz@neuro.med.uni-erlangen.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Autonomic Nervous System / physiopathology
Baroreflex / physiology*
Blood Pressure / physiology
Cerebrovascular Circulation / physiology
Electrocardiography
Epilepsy, Complex Partial / physiopathology
Epilepsy, Temporal Lobe / physiopathology*
Female
Heart Rate / physiology
Humans
Male
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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