| Impaired baroreflex function and arterial compliance in primary aldosteronism. | |
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MedLine Citation:
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PMID: 9928749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to evaluate if changes in vascular properties were related to baroreflex function in patients with primary aldosteronism. Twenty-three patients with primary aldosteronism, 22 essential hypertensive patients and 16 normal controls were studied. Continuous finger blood pressure (BP) was recorded by Portapres device during supine rest and active stand up. Compliance was estimated from the time constant of pressure decay during diastole. Baroreflex sensitivity was calculated by autoregressive cross-spectral analysis of systolic BP and interbeat interval. The result was that baroreflex gain and compliance were lower in primary aldosteronism patients in the supine position (P = 0.002 and P < 0.05 respectively). Aldosterone plasma levels (R2 = 0.31, P = 0.01), age, systolic and diastolic BP, high and low frequency components of diastolic BP variability were independently related to compliance in primary aldosteronism. In conclusion primary aldosteronism is associated with an impaired baroreflex function related in part to a reduced arterial compliance. Despite a reduction of BP values and aldosterone levels, surgical or pharmacological treatment did not significantly change compliance values. |
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Authors:
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F Veglio; P Molino; G Cat Genova; R Melchio; F Rabbia; T Grosso; G Martini; L Chiandussi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of human hypertension Volume: 13 ISSN: 0950-9240 ISO Abbreviation: J Hum Hypertens Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-04-13 Completed Date: 1999-04-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8811625 Medline TA: J Hum Hypertens Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 29-36 Citation Subset: IM |
Affiliation:
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Department of Medicine and Experimental Oncology, University of Turin, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aldosterone / blood Arteries / physiopathology* Baroreflex / physiology* Blood Pressure / physiology Compliance Female Heart Rate / physiology Hemodynamics / physiology Humans Hyperaldosteronism / blood, physiopathology*, therapy Hypertension / physiopathology Male Middle Aged Reference Values Vascular Resistance / physiology |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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