Document Detail


Impaired bactericidal but not fungicidal activity of polymorphonuclear neutrophils in patients with chronic lymphocytic leukemia.
MedLine Citation:
PMID:  23163595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the qualitative polymorphonuclear neutrophil (PMN)-associated immune impairment in patients with chronic lymphocytic leukemia (CLL) by characterizing phagocytic killing of key non-opsonized bacterial (Staphylococcus aureus and Pseudomonas aeruginosa) and fungal (Candida albicans and Aspergillus fumigatus) pathogens. Neutrophils were collected from 47 non-neutropenic patients with CLL (PMN count > 1000/mm(3)) and age-matched and young healthy controls (five each). A subset of patients (13%) had prior or subsequent infections. We found that the patients with CLL had diminished PMN microbicidal response against bacteria but not against fungi compared with the controls. Compared to patients with effective PMN responses, we did not identify differences of basal PMN pathogen-associated molecular pattern receptor gene expression, soluble pathogen-associated molecular pattern gene expression or inflammatory cytokine signatures in patients with impaired PMN responses when PMNs were analyzed in multiplex real-time polymerase chain reaction assays. However, differences in PMN microbicidal response against A. fumigatus in patients with CLL were associated with the degree of hypogammaglobulinemia.
Authors:
Dimitrios P Kontoyiannis; Sarah P Georgiadou; William G Wierda; Susan Wright; Nathaniel D Albert; Alessandra Ferrajoli; Michael Keating; Russell E Lewis
Related Documents :
16105845 - Provocation of sudden heart rate oscillation with adenosine exposes abnormal qt respons...
11914245 - Prevalence of anderson-fabry disease in male patients with late onset hypertrophic card...
23959705 - An extended leukocyte differential count (16 types of circulating leukocytes) using the...
23411705 - Absent or extremely low neutrophil alkaline phosphatase activity levels in patients wit...
17581335 - Axillary lymph node visualization on f-18 fdg pet body scans in patients with rheumatoi...
12220475 - Evaluation of serum eosinophil cationic protein as a predictive marker for asthma exace...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-02-20
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  54     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-15     Completed Date:  2014-02-24     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  England    
Other Details:
Languages:  eng     Pagination:  1730-3     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Bacterial Infections / immunology*
Female
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / immunology*,  pathology
Male
Middle Aged
Mycoses / immunology*
Neoplasm Staging
Neutrophils / immunology*,  metabolism
Prospective Studies
Grant Support
ID/Acronym/Agency:
CA016672/CA/NCI NIH HHS; P01 CA081534/CA/NCI NIH HHS; P30 CA016672/CA/NCI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hydroxocobalamin in cyanide poisoning.
Next Document:  Stability of nucleosomes containing homogenously ubiquitylated H2A and H2B prepared using semisynthe...