| Impaired autophagy underlies key pathological responses of acute pancreatitis. | |
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MedLine Citation:
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PMID: 20215882 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The main function of the exocrine pancreas is to produce digestive enzymes, which normally are secreted as inactive zymogens and become activated after reaching the duodenum. Pancreatitis is a relatively common and potentially fatal inflammatory disease of the exocrine pancreas. Its mild forms are self-limited, but severe pancreatitis has 10%-30% mortality. The pathogenesis of pancreatitis remains obscure, and there are no specific treatments. The disease is believed to initiate in acinar cells, the main cell type of the exocrine pancreas. Hallmark responses of acute pancreatitis are the premature, intra-acinar cell activation of trypsinogen (i.e., its conversion from zymogen to active trypsin), vacuole accumulation, inflammation and death of acinar cells through both necrosis and apoptosis. |
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Authors:
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Ilya Gukovsky; Anna S Gukovskaya |
Publication Detail:
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Type: Journal Article Date: 2010-04-15 |
Journal Detail:
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Title: Autophagy Volume: 6 ISSN: 1554-8635 ISO Abbreviation: Autophagy Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-23 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: United States |
Other Details:
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Languages: eng Pagination: 428-9 Citation Subset: IM |
Affiliation:
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VA Greater Los Angeles Healthcare System and University of California, Los Angeles, Los Angeles, CA, USA. igukovsk@ucla.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autophagy
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physiology* Cathepsin B / metabolism Humans Lysosomes / metabolism Pancreatitis, Acute Necrotizing / mortality, pathology*, physiopathology Trypsin / metabolism Vacuoles / metabolism |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.4/Trypsin; EC 3.4.22.1/Cathepsin B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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