Document Detail

Impaired antioxidant defense in hemoglobin E-containing erythrocytes: a mechanism protective against malaria?
MedLine Citation:
PMID:  3674003     Owner:  NLM     Status:  MEDLINE    
Red blood cell (RBC) antioxidant defense was investigated in eight individuals with hemoglobin E (Six EE and two E-B(+) thalassemia) and compared to that in six individuals with thalassemia and ten normal subjects. Individuals with hemoglobin E had increased incubated Heinz body formation (68% +/- 18%; p less than 0.001) compared to normal and thalassemic RBC (10% +/- 2% and 11% +/- 5%, respectively). Stimulated pentose phosphate shunt activity was increased in the thalassemic and decreased in the hemoglobin E RBC as compared to normal. The 2,3-diphosphoglycerate (DPG) content of the EE RBC was increased to 5.59 +/- 0.69 mumol/ml RBC as compared to normal (4.51 +/- 0.77; p less than 0.001). In the EE RBC, there was a direct correlation between Heinz body formation and DPG content (r = 0.73). Ascorbic and dehydroascorbic acid (0.1 and 1.0 mM) were able to decrease the degree of Heinz body formation in the hemoglobin E RBC. Ascorbic acid (0.1 mM) prolonged the response of the pentose shunt. Thus impaired antioxidant defense may account for the persistence of the hemoglobin E gene in areas where malaria is endemic. Oxidant medications should be used with caution in individuals of Southeast Asian origin.
N A Lachant; K R Tanaka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hematology     Volume:  26     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-09     Completed Date:  1987-12-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  211-9     Citation Subset:  IM    
Department of Medicine, Harbor-UCLA Medical Center, Torrance 90502.
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MeSH Terms
Antioxidants / chemistry*
Ascorbic Acid / pharmacology
Diphosphoglyceric Acids / blood
Erythrocytes / drug effects,  metabolism*,  ultrastructure
Glutathione / blood
Heinz Bodies / drug effects,  ultrastructure
Hemoglobin A / metabolism
Hemoglobin E / metabolism*
Hemoglobins, Abnormal / metabolism*
Malaria / blood*,  prevention & control
Pentose Phosphate Pathway / drug effects
Thalassemia / blood*
Grant Support
Reg. No./Substance:
0/Antioxidants; 0/Diphosphoglyceric Acids; 0/Hemoglobins, Abnormal; 138-81-8/2,3-Diphosphoglycerate; 50-81-7/Ascorbic Acid; 70-18-8/Glutathione; 9034-51-9/Hemoglobin A; 9034-61-1/Hemoglobin E

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