Document Detail

Impaired antioxidant activity in women with pre-eclampsia.
MedLine Citation:
PMID:  10189019     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate antioxidant activity of sera and the plasma blood levels of two potent antioxidant in women with pre-eclampsia and normotensive pregnancies. STUDY DESIGN: The antioxidant activity of sera and the blood levels of ascorbic acid and alpha-tocopherol were assayed in women with normal pregnancies (n = 33), mild pre-eclampsia (n = 8), and severe pre-eclampsia (n = 16) between 20 and 40 weeks' gestation. Ascorbic acid and alpha-tocopherol concentrations were analyzed by high-performance liquid chromatography. Antioxidant activity of sera was measured as the percent inhibition of spontaneous autoxidation of a standard brain homogenate. RESULTS: Plasma levels of ascorbic acid in women with mild and severe pre-eclampsia were significantly lower than normal pregnancies (P < 0.05). Sera alpha-tocopherol levels were significantly decreased only in severe pre-eclampsia (P < 0.05). Sera antioxidant activity were significantly decreased in mild (73%) and severe (51%) pre-eclampsia compared with normal (86%) pregnancies (P = 0.02, P = 0.000, respectively). CONCLUSIONS: In women with pre-eclampsia, sera antioxidant activity and antioxidant level of plasma are decreased when compared with normotensive pregnancies. Impaired antioxidant activity and the reduction of antioxidant levels which increase the level of lipid peroxidation products may cause peroxidative damage of vascular endothelium and result in clinical symptoms of pre-eclampsia.
S Sağol; E Ozkinay; S Ozşener
Related Documents :
6940569 - Treatment of severe pre-eclampsia by plasma exchange.
8378539 - Effects of a thromboxane synthetase inhibitor on platelet function; possible risks of u...
16836609 - Circulating endothelial progenitor cells during normal pregnancy and pre-eclampsia.
3923569 - Control of prostacyclin synthesis in pregnancy-induced hypertension.
9853769 - Circulating markers of oxidative stress are raised in normal pregnancy and pre-eclampsia.
7906809 - Clasp: a randomised trial of low-dose aspirin for the prevention and treatment of pre-e...
2437799 - Declining serum concentrations of the beta-subunit of human chorionic gonadotropin and ...
3377319 - Seasonal prevalence of gastrointestinal nematodes of beef calves grazed on irrigated pa...
3191859 - Chronic maternal hypoxia. effect of mid-gestational maternal hypoxia on methionine-enke...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  64     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-05-17     Completed Date:  1999-05-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  121-7     Citation Subset:  IM    
Aegean University of Medical Faculty, Department of Obstetrics and Gynecology, Izmir, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antioxidants / metabolism*
Ascorbic Acid / blood*
Case-Control Studies
Chromatography, High Pressure Liquid
Lipid Peroxidation*
Pre-Eclampsia / blood*,  etiology
Vitamin E / blood*
Reg. No./Substance:
0/Antioxidants; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Three dimensional volume measurement of the cervix during pregnancy compared to conventional 2D-sono...
Next Document:  Biophysical profile score in late pregnancy and timing of delivery.