| Impaired alpha-carboxyamidation of gastrin in vitamin C-deficient guinea pigs. | |
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MedLine Citation:
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PMID: 3943627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The biosynthetic activation of many hormonal peptides requires enzymatic alpha-carboxyamidation via glycine-extended intermediate forms. By specific radioimmunochemical measurement on extracts of guinea pig antra, we found that vitamin C deficiency induced a 30-fold increase in glycine-extended (i.e. inactive) gastrins. The results indicate that ascorbic acid is necessary for alpha-carboxyamidation in vivo, and thus, that the biosynthetic activation of hormonal peptides can be modified by simple dietary means. |
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Authors:
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L Hilsted; J F Rehfeld; T W Schwartz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 196 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1986 Feb |
Date Detail:
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Created Date: 1986-03-17 Completed Date: 1986-03-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 151-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ascorbic Acid / physiology Diet Gastrins / metabolism* Glycine / metabolism Guinea Pigs Peptide Fragments / analysis Scurvy / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 0/Peptide Fragments; 50-81-7/Ascorbic Acid; 56-40-6/Glycine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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