Document Detail

Impaired aldosterone production by long-term infusion of atrial natriuretic factor.
MedLine Citation:
PMID:  2137294     Owner:  NLM     Status:  MEDLINE    
This study assessed the effect of chronic infusions of atrial natriuretic factor (ANF) on in vivo and in vitro production of aldosterone. Vehicle (saline) or rat ANF-(99-126) was intravenously infused at 100 for 5 consecutive days into male New Zealand White rabbits. At 5 days plasma ANF was 18 +/- 4.1 pg/ml in vehicle-infused and 48.5 +/- 9.0 in ANF-infused rabbits (P less than 0.01). Plasma renin activity was significantly less in ANF-infused rabbits (2.99 +/- 0.35 vs. 0.77 +/- 0.12, P less than 0.01); however no differences were observed in the basal plasma concentrations of aldosterone, corticosterone, potassium, or hematocrit. In in vivo studies, chronically administered ANF attenuated plasma aldosterone, but not pressor, responses to acutely infused angiotensin II given at doses of 4, 16, and 64 for 20 min each. In in vitro experiments, collagenase-dispersed adrenal capsular cells from ANF-infused rabbits exhibited significantly reduced maximal responses to adrenocorticotropic hormone, angiotensin II, and potassium. These results suggest that chronic small increases in circulating ANF can blunt selectively adrenocortical responses to aldosterone secretagogues without affecting pressor responses to angiotensin II.
M Nagano; E L Bravo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  258     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-03-01     Completed Date:  1990-03-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E51-6     Citation Subset:  IM    
Department of Heart and Hypertension, Cleveland Clinic Foundation, Ohio 44195.
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MeSH Terms
Adrenal Medulla / drug effects,  metabolism
Aldosterone / biosynthesis,  blood*
Aldosterone Antagonists
Angiotensin II / administration & dosage,  pharmacology*
Atrial Natriuretic Factor / administration & dosage,  pharmacology*
Blood Pressure / drug effects
Cosyntropin / pharmacology
Diuretics / pharmacology*
Drug Administration Schedule
Infusions, Intravenous
Peptide Fragments / administration & dosage,  pharmacology*
Reference Values
Reg. No./Substance:
0/Aldosterone Antagonists; 0/Diuretics; 0/Peptide Fragments; 11128-99-7/Angiotensin II; 16960-16-0/Cosyntropin; 52-39-1/Aldosterone; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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