Document Detail


Impaired aldosterone production by long-term infusion of atrial natriuretic factor.
MedLine Citation:
PMID:  2137294     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study assessed the effect of chronic infusions of atrial natriuretic factor (ANF) on in vivo and in vitro production of aldosterone. Vehicle (saline) or rat ANF-(99-126) was intravenously infused at 100 ng.kg-1.h-1 for 5 consecutive days into male New Zealand White rabbits. At 5 days plasma ANF was 18 +/- 4.1 pg/ml in vehicle-infused and 48.5 +/- 9.0 in ANF-infused rabbits (P less than 0.01). Plasma renin activity was significantly less in ANF-infused rabbits (2.99 +/- 0.35 vs. 0.77 +/- 0.12 ng.ml-1.h-1, P less than 0.01); however no differences were observed in the basal plasma concentrations of aldosterone, corticosterone, potassium, or hematocrit. In in vivo studies, chronically administered ANF attenuated plasma aldosterone, but not pressor, responses to acutely infused angiotensin II given at doses of 4, 16, and 64 ng.kg-1.min-1 for 20 min each. In in vitro experiments, collagenase-dispersed adrenal capsular cells from ANF-infused rabbits exhibited significantly reduced maximal responses to adrenocorticotropic hormone, angiotensin II, and potassium. These results suggest that chronic small increases in circulating ANF can blunt selectively adrenocortical responses to aldosterone secretagogues without affecting pressor responses to angiotensin II.
Authors:
M Nagano; E L Bravo
Related Documents :
7716064 - Central c-type natriuretic peptide augments the hormone response to hemorrhage in consc...
8076074 - Effect of right atrial appendicectomy on the release of atrial natriuretic peptide in h...
15609694 - Evaluation of neurohumoral activation (adrenomedullin, bnp, catecholamines, etc.) in pa...
2524174 - Physiological doses of atrial peptide inhibit angiotensin ii-stimulated aldosterone sec...
8413314 - Gonadal steroid hormone regulation of human and mouse follicle stimulating hormone beta...
263304 - Fetal hypothyroidism and maternal thyroid status in severe endemic goiter.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  258     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-03-01     Completed Date:  1990-03-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E51-6     Citation Subset:  IM    
Affiliation:
Department of Heart and Hypertension, Cleveland Clinic Foundation, Ohio 44195.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenal Medulla / drug effects,  metabolism
Aldosterone / biosynthesis,  blood*
Aldosterone Antagonists
Angiotensin II / administration & dosage,  pharmacology*
Animals
Atrial Natriuretic Factor / administration & dosage,  pharmacology*
Blood Pressure / drug effects
Cosyntropin / pharmacology
Diuretics / pharmacology*
Drug Administration Schedule
Infusions, Intravenous
Kinetics
Male
Peptide Fragments / administration & dosage,  pharmacology*
Rabbits
Reference Values
Chemical
Reg. No./Substance:
0/Aldosterone Antagonists; 0/Diuretics; 0/Peptide Fragments; 11128-99-7/Angiotensin II; 16960-16-0/Cosyntropin; 52-39-1/Aldosterone; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Relative efficacy of slow and fast alpha-motoneurons to reinnervate mouse soleus muscle.
Next Document:  Native tubular fluid attenuates ANF-induced inhibition of tubuloglomerular feedback.