Document Detail


Impaired alcohol metabolism after gastric bypass surgery: a case-crossover trial.
MedLine Citation:
PMID:  21183366     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Severe obesity remains the leading public health crisis of the industrialized world, with bariatric surgery the only effective and enduring treatment. Poor psychological adjustment has been occasionally reported postoperatively. In addition, evidence suggests that patients can metabolize alcohol differently after gastric bypass.
STUDY DESIGN: Preoperatively and at 3 and 6 months postoperatively, 19 Roux-en-Y gastric bypass (RYGB) patients' breath alcohol content (BAC) was measured every 5 minutes after drinking 5 oz red wine to determine peak BAC and time until sober in a case-crossover design preoperatively and at 6 months postoperatively.
RESULTS: Patients reported symptoms experienced when intoxicated and answered a questionnaire of drinking habits. The peak BAC in patients after RYGB was considerably higher at 3 months (0.059%) and 6 months (0.088%) postoperatively than matched preoperative levels (0.024%). Patients also took considerably more time to return to sober at 3 months (61 minutes) and 6 months (88 minutes) than preoperatively (49 minutes). Postoperative intoxication was associated with lower levels of diaphoresis, flushing, and hyperactivity and higher levels of dizziness, warmth, and double vision. Postoperative patients reported drinking considerably less alcohol, fewer preferred beer, and more preferred wine than before surgery.
CONCLUSIONS: This is the first study to match preoperative and postoperative alcohol metabolism in gastric bypass patients. Post-RYGB patients have much higher peak BAC after ingesting alcohol and require more time to become sober. Patients who drink alcohol after gastric bypass surgery should exercise caution.
Authors:
Gavitt A Woodard; John Downey; Tina Hernandez-Boussard; John M Morton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-22
Journal Detail:
Title:  Journal of the American College of Surgeons     Volume:  212     ISSN:  1879-1190     ISO Abbreviation:  J. Am. Coll. Surg.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-31     Completed Date:  2011-03-07     Revised Date:  2011-10-05    
Medline Journal Info:
Nlm Unique ID:  9431305     Medline TA:  J Am Coll Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  209-14     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 American College of Surgeons. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Surgery, Section of Minimally Invasive and BariatricSurgery, Stanford University School of Medicine, Stanford, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Drinking / adverse effects*
Alcoholic Intoxication / diagnosis*,  metabolism
Body Mass Index
Breath Tests
Case-Control Studies
Central Nervous System Depressants / adverse effects,  metabolism*
Ethanol / adverse effects,  metabolism*
Female
Gastric Bypass / adverse effects*
Humans
Linear Models
Male
Middle Aged
Obesity / surgery
Postoperative Period
Preoperative Period
Questionnaires
Chemical
Reg. No./Substance:
0/Central Nervous System Depressants; 64-17-5/Ethanol
Comments/Corrections
Comment In:
J Am Coll Surg. 2011 Sep;213(3):451; author reply 451-2   [PMID:  21871384 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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