Document Detail


Impaired adult myelination in the prefrontal cortex of socially isolated mice.
MedLine Citation:
PMID:  23143512     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Protracted social isolation of adult mice induced behavioral, transcriptional and ultrastructural changes in oligodendrocytes of the prefrontal cortex (PFC) and impaired adult myelination. Social re-integration was sufficient to normalize behavioral and transcriptional changes. Short periods of isolation affected chromatin and myelin, but did not induce behavioral changes. Thus, myelinating oligodendrocytes in the adult PFC respond to social interaction with chromatin changes, suggesting that myelination acts as a form of adult plasticity.
Authors:
Jia Liu; Karen Dietz; Jacqueline M DeLoyht; Xiomara Pedre; Dipti Kelkar; Jasbir Kaur; Vincent Vialou; Mary Kay Lobo; David M Dietz; Eric J Nestler; Jeffrey Dupree; Patrizia Casaccia
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-11
Journal Detail:
Title:  Nature neuroscience     Volume:  15     ISSN:  1546-1726     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-28     Completed Date:  2013-01-29     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1621-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Male
Mice
Mice, Inbred C57BL
Myelin Sheath / pathology*,  ultrastructure
Nerve Fibers, Myelinated / pathology*,  ultrastructure
Oligodendroglia / pathology,  ultrastructure
Prefrontal Cortex / pathology*,  ultrastructure
Social Isolation / psychology*
Grant Support
ID/Acronym/Agency:
5P30NS047463/NS/NINDS NIH HHS; P50-MH96890/MH/NIMH NIH HHS; R37 NS042925/NS/NINDS NIH HHS; R37-NS42925-10/NS/NINDS NIH HHS
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