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Impaired β-adrenergic receptor signaling in post-resuscitation myocardial dysfunction.
MedLine Citation:
PMID:  22115934     Owner:  NLM     Status:  Publisher    
OBJECTIVE: Post-resuscitation myocardial dysfunction is a major cause of fatality in patients receiving successful cardiopulmonary resuscitation. The mechanism of post-resuscitation myocardial dysfunction is largely unknown, although is generally considered related to ischemia occurring during cardiac arrest and resuscitation and/or reperfusion injury after restoration of circulation. A key mechanism responsible for reduced contractile reserves in chronic heart failure is impaired β-adrenergic receptor signaling. Thus, we hypothesized that β-adrenergic receptor signaling is markedly abnormal in the post-resuscitation period following cardiopulmonary resuscitation. METHODS: Male landrace domestic pigs were randomized into a sham group (anesthetized and instrumented, no ventricular fibrillation) or cardiopulmonary resuscitation (CPR) group (ventricular fibrillation) (n=8 per group). Hemodynamic and echocardiographic data were recorded. β-adrenergic receptor signaling was assessed at 6h after the operation by measuring myocardial adenylate cyclase activity, β-adrenergic receptor density, and β-adrenergic receptor kinase expression. RESULTS: Left ventricular function in the CPR group was significantly decreased at 6h after restoration of spontaneous circulation. Basal and isoproterenol-stimulated adenylate cyclase activity was blunted in the CPR group compared with the sham group. Total β-AR density was significantly decreased in CPR group compared with the sham group. Myocardial β-adrenergic receptor kinase expression was 2.17-fold greater in the CPR group than the sham group. CONCLUSIONS: β- adrenergic receptor signaling is markedly impaired in the post-resuscitation period, which may be a mechanism of post-resuscitation myocardial dysfunction.
Xian-Fei Ji; Shuo-Wang; Lin Yang; Chun-Sheng Li
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-21
Journal Detail:
Title:  Resuscitation     Volume:  -     ISSN:  1873-1570     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ireland Ltd.
Department of emergency, Provincial Hospital Affiliated to Shandong University, Jinan, China; Department of emergency, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
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