| Impaired activation of caspase cascade during cell death induced by newly synthesized singlet oxygen generator, 1-buthylnaphthalene-4-propionate endoperoxide. | |
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MedLine Citation:
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PMID: 18782624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endoperoxides of naphthalene derivatives generate singlet oxygen under physiological conditions. Here we have synthesized a new endoperoxide of a naphthalene derivative, 1-buthylnaphthalene-4-propionate endoperoxide (BNPE), and studied its cytotoxic properties on HepG2 and HaCaT cells. BNPE induced cell death at much lower concentration than 1-methylnaphthalene-4-propionate endoperoxide (MNPE) and naphthalene dipropionate endoperoxide (NDPE). A positive correlation exists between the amount of endoperoxide incorporated into cells and its cytotoxic ability. The cytotoxic effect of BNPE was attenuated by alpha-tocopherol but not by sodium azide. In contrast, the effects of MNPE and NDPE were attenuated by both alpha-tocopherol and sodium azide. The caspase cascade in cells treated with endoperoxide was impaired. Caspase activity in a soluble protein fraction were inhibited similarly by the above three endoperoxides. These results suggest an abortive apoptotic pathway due to the suppression of caspase activation is a general feature of cell death induced by singlet oxygen. |
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Authors:
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Kaoru Otsu; Kazuaki Sato; Michihiko Sato; Hideyu Ono; Yoshihiro Ohba; Yohtaro Katagata |
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Publication Detail:
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Type: Journal Article Date: 2008-08-20 |
Journal Detail:
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Title: Cell biology international Volume: 32 ISSN: 1095-8355 ISO Abbreviation: Cell Biol. Int. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-28 Completed Date: 2009-01-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307129 Medline TA: Cell Biol Int Country: England |
Other Details:
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Languages: eng Pagination: 1380-7 Citation Subset: IM |
Affiliation:
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Environmental Preservation Center, Yamagata University, Yamagata, Japan. yootsu@med.id.yamagata-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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pharmacology Apoptosis* / drug effects, physiology Caspases / drug effects*, metabolism Cell Line Cell Line, Tumor Cytotoxins / toxicity DNA Fragmentation / drug effects Humans Lipid Peroxides / pharmacology Naphthalenes / toxicity* Oxidants / toxicity Oxidative Stress / drug effects, physiology Peroxides / pharmacology*, toxicity Propionates / pharmacology Signal Transduction / drug effects*, physiology Singlet Oxygen / toxicity* Sodium Azide / pharmacology alpha-Tocopherol / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/1-butylnaphthalene-4-propionic acid endoperoxide; 0/3-(4'-methyl-1'-naphthyl)propionic acid 1',4'-endoperoxide; 0/Antioxidants; 0/Cytotoxins; 0/Lipid Peroxides; 0/Naphthalenes; 0/Oxidants; 0/Peroxides; 0/Propionates; 17778-80-2/Singlet Oxygen; 26628-22-8/Sodium Azide; 59-02-9/alpha-Tocopherol; EC 3.4.22.-/Caspases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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