Document Detail


Impaired Myogenic Tone in Isolated Cerebral and Coronary Resistance Arteries from the Goto-Kakizaki Rat Model of Type 2 Diabetes.
MedLine Citation:
PMID:  22508433     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim: Type 2 diabetes is associated with stroke and cardiac dysfunction. We therefore investigated isolated middle cerebral arteries and coronary septal arteries from the diabetic Goto-Kakizaki (GK) rat model of nonobese type 2 diabetes. Methods: Myogenic tone and agonist-induced responses were investigated under isobaric conditions with simultaneous recording of [Ca(2+)](i). Rho-kinase and NO pathways were investigated using specific pharmacological tools. Results: Arteries from GK rats developed less tone at pressures from 20 to 100 mm Hg than arteries from control Wistar (CW) rats while [Ca(2+)](i) was similar. Blocking the Rho-kinase pathway decreased the pressure-induced development of tone and after blockade no difference in myogenic tone between arteries from GK and CW rats was seen. Cerebral arteries had similar tone to a maximal concentration of U46619 (GK: 35.5 ± 2% vs. CW: 31.6 ± 5%), while coronary arteries from GK rats developed less tone than arteries from CW rats (12 ± 3 vs. 26.1 ± 3%). Endothelium-dependent vasodilation to A23187 (cerebral) and to acetylcholine (coronary) was not different between arteries from GK and CW rats. Conclusion: Our data suggest that in resistance arteries from the brain and the heart of GK rats the myogenic tone is decreased due to impaired calcium sensitivity likely due to a defective Rho-kinase pathway.
Authors:
H Kold-Petersen; E Brøndum; H Nilsson; A Flyvbjerg; C Aalkjaer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-11
Journal Detail:
Title:  Journal of vascular research     Volume:  49     ISSN:  1423-0135     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9206092     Medline TA:  J Vasc Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  267-278     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
NeuroSearch A/S, Ballerup, Denmark.
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