| Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus. | |
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MedLine Citation:
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PMID: 21398396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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West Nile virus (WNV), a mosquito-borne, single-stranded RNA flavivirus, causes significant human morbidity and mortality in the older population; thus, we investigated the effects of aging on infection with WNV in dendritic cells (DCs). We infected DCs with WNV in vitro and quantified cytokines and chemokines (type I IFN and CXCL10), pathogen recognition receptors RIG-I, and Toll-like receptors 3 and 7. The production of type I IFN was significantly lower in DCs from older donors, compared with younger donors. Although we observed no significant age-related difference in expression or nuclear translocation of signaling molecules in initial antiviral responses, DCs from older donors have diminished induction of late-phase responses (eg, STAT1, IRF7, and IRF1), suggesting defective regulation of type I IFN. Our results identify deficits in critical regulatory pathways in the antiviral response that may contribute to the enhanced susceptibility to viral infections observed in aging. |
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Authors:
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Feng Qian; Xiaomei Wang; Lin Zhang; Aiping Lin; Hongyu Zhao; Erol Fikrig; Ruth R Montgomery |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-03-11 |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 203 ISSN: 1537-6613 ISO Abbreviation: J. Infect. Dis. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-19 Completed Date: 2011-06-30 Revised Date: 2012-05-15 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1415-24 Citation Subset: AIM; IM |
Affiliation:
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Section of Rheumatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Aging / immunology* Dendritic Cells / immunology* Female Humans Interferons / physiology* Leukocytes, Mononuclear / immunology Male Middle Aged Signal Transduction / immunology* West Nile Fever / immunology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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AI 070343/AI/NIAID NIH HHS; AI 50031/AI/NIAID NIH HHS; M01-RR00125/RR/NCRR NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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9008-11-1/Interferons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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