| Impaired glucose tolerance and insulin resistance in survivors of childhood acute lymphoblastic leukemia: prevalence and risk factors. | |
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MedLine Citation:
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PMID: 20485196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PATIENTS AND METHODS: In 131 ALL survivors, an oral glucose tolerance test was conducted to determine beta-cell function/insulin sensitivity. The particular risk factors were analyzed and 6 single nucleotide polymorphisms of diabetic predisposing genes: PAX4 and TCF7L2 were genotyped to evaluate the association between these factors and beta-cell function/insulin sensitivity. RESULTS: Ten out of 131 survivors (7.6%) had impaired glucose tolerance (IGT) whereas 40 out of 131 (30.5%) had insulin resistance (IR) and showed characteristics of the metabolic syndrome (hyperinsulinemia, hypertriglyceridemia, and low HDL-C). In the logistic regression analysis, the most important factor predicting IGT and IR was older age of survivors (P=0.014 and P<0.001, respectively) whereas the PAX4 R192H mutation (rs2233580) was significantly associated with IGT after adjustment for age (P=0.043) (adjusted OR 5.28, 95% CI 1.06-26.40). CONCLUSIONS: Existing evidence suggests that older age is an independent risk factor for developing IGT and IR in childhood ALL survivors, emphasizing the need for life-long metabolic screening. The PAX4 variant might impact individual susceptibility against IGT and diabetes. However, an identification of underlying risk(s) is the rational for future studies. |
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Authors:
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Pacharapan Surapolchai; Suradej Hongeng; Pat Mahachoklertwattana; Samart Pakakasama; Angkana Winaichatsak; Nittaya Wisanuyothin; Ekawat Pasomsub; Surakameth Mahasirimongkol; Nongnuch Sirachainan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 32 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-07 Completed Date: 2010-08-03 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 383-9 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Blood Glucose / metabolism* Child Child, Preschool DNA, Neoplasm / genetics Female Glucose Tolerance Test* Homeodomain Proteins / genetics Humans Infant Insulin Resistance* Male Paired Box Transcription Factors / genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood*, genetics Prevalence Risk Factors Sex Factors Survival Rate Survivors Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/DNA, Neoplasm; 0/Homeodomain Proteins; 0/PAX4 protein, human; 0/Paired Box Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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