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Impaired Fasting Glucose Association With Mortality in Nondiabetic Patients on Maintenance Peritoneal Dialysis.
MedLine Citation:
PMID:  21289510     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION:: The aim of this study was to investigate clinical significance of impaired fasting glucose (IFG) in nondiabetic patients on maintenance peritoneal dialysis (PD). METHODS:: In total, 362 maintenance PD patients were enrolled and followed up for 2-years. According to 1997 definitions, patients were divided into 3 groups: diabetic (n = 85), nondiabetic with IFG (n = 62) and nondiabetic with normal fasting glucose levels (n = 215). After basal data were collected for cross-sectional analyses, mortality and cause of death were recorded for longitudinal analyses. RESULTS:: After adjusting for related variables by multivariate logistic regression analysis, IFG was found to be positively associated with age but negatively associated with normalized protein nitrogen appearance and transferrin saturation in nondiabetic maintenance PD patients. Thirty nondiabetic patients had died after the 2-year follow-up. Cox multivariate analysis showed that age (hazard ratio: 1.037; 95% confidence interval: 1.002-1.073; P = 0.036) and presence of IFG (hazard ratio: 2.719; 95% confidence interval: 1.082-6.833; P = 0.033) were significant risk factors for all-cause 2-year mortality in nondiabetic maintenance PD patients. CONCLUSIONS:: IFG, a preventable and treatable condition, was associated with all-cause 2-year mortality in nondiabetic maintenance PD patients.
Authors:
Kuan-Hsing Chen; Ja-Liang Lin; Cheng-Chieh Hung; Dan-Tzu Lin-Tan; Shu-Man Weng; Tzung-Hai Yen; Ching-Wei Hsu; Chih-Wei Yang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-1
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  -     ISSN:  1538-2990     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Division of Clinical Toxicology (k-hc, j-ll, c-ch, d-tl-t, s-mw, t-hy, c-wh, c-wy), Department of Nephrology, Chang Gung Memorial Hospital, Lin-Kou Medical Center, Taipei, Taiwan, People's Republic of China; and School of Medicine (k-hc, j-ll, c-ch, d-tl-t, t-hy, c-wh, c-wy), Chang Gung University, Taipei, Taiwan, People's Republic of China.
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