Document Detail


Impaired executive function mediates the association between maternal pre-pregnancy body mass index and child ADHD symptoms.
MedLine Citation:
PMID:  22719848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Increasing evidence suggests exposure to adverse conditions in intrauterine life may increase the risk of developing attention-deficit/hyperactivity disorder (ADHD) in childhood. High maternal pre-pregnancy body mass index (BMI) has been shown to predict child ADHD symptoms, however the neurocognitive processes underlying this relationship are not known. The aim of the present study was to test the hypothesis that this association is mediated by alterations in child executive function.
METHODOLOGY/PRINCIPAL FINDINGS: A population-based cohort of 174 children (mean age = 7.3 ± 0.9 (SD) yrs, 55% girls) was evaluated for ADHD symptoms using the Child Behavior Checklist, and for neurocognitive function using the Go/No-go task. This cohort had been followed prospectively from early gestation and birth through infancy and childhood with serial measures of maternal and child prenatal and postnatal factors. Maternal pre-pregnancy BMI was a significant predictor of child ADHD symptoms (F((1,158)) = 4.80, p = 0.03) and of child performance on the Go/No-go task (F((1,157)) = 8.37, p = 0.004) after controlling for key potential confounding variables. A test of the mediation model revealed that the association between higher maternal pre-pregnancy BMI and child ADHD symptoms was mediated by impaired executive function (inefficient/less attentive processing; Sobel Test: t = 2.39 (± 0.002, SEM), p = 0.02).
CONCLUSIONS/SIGNIFICANCE: To the best of our knowledge this is the first study to report that maternal pre-pregnancy BMI-related alterations in child neurocognitive function may mediate its effects on ADHD risk. The finding is clinically significant and may extrapolate to an approximately 2.8-fold increase in the prevalence of ADHD among children of obese compared to those of non-obese mothers. These results add further evidence to the growing awareness that neurodevelopmental disorders such as ADHD may have their foundations very early in life.
Authors:
Claudia Buss; Sonja Entringer; Elysia Poggi Davis; Calvin J Hobel; James M Swanson; Pathik D Wadhwa; Curt A Sandman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-06-15
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-21     Completed Date:  2012-12-13     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e37758     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Attention Deficit Disorder with Hyperactivity / physiopathology*,  psychology
Body Mass Index*
Child
Cohort Studies
Executive Function*
Female
Humans
Male
Pregnancy
Grant Support
ID/Acronym/Agency:
HD-28413/HD/NICHD NIH HHS; HD-51852/HD/NICHD NIH HHS; NS-41298/NS/NINDS NIH HHS; R01 HD-050662/HD/NICHD NIH HHS; R01 HD-06028/HD/NICHD NIH HHS; R01 HD-065825/HD/NICHD NIH HHS; R01 HD060628/HD/NICHD NIH HHS; R01 MH-091351/MH/NIMH NIH HHS; R01 MH091351/MH/NIMH NIH HHS
Comments/Corrections

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