| Impaired Cytokine Production and Decreased TLR2-Mediated Signaling in Mouse Infant Macrophages. | |
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MedLine Citation:
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PMID: 22443189 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Infants are known to be more susceptible to pathogens. This might be due in part to the impaired function of macrophage. In the present study, we observed that macrophages from infant mice produced decreased levels of TNF-α and IL-6, but increased IL-10 after stimulation with toll-like receptor 2 (TLR2) agonist zymosan. Moreover, zymosan-stimulated activation of mitogen-activated protein kinase (MAPK) p38 and ERK1/2 was significantly reduced in mouse infant macrophages. These effects could be reversed by using MAPK modulators. The findings suggest that the impaired cytokine production and decreased TLR2-mediated signaling in infant macrophages may contribute to the susceptibility of infants to bacterial infection. |
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Authors:
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Guoji Zhu; Xuhua Ge; Jie Zhu; Yan Wei; Jian Wang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-23 |
Journal Detail:
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Title: Fetal and pediatric pathology Volume: - ISSN: 1551-3823 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101230972 Medline TA: Fetal Pediatr Pathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Soochow University Affiliated Children's Hospital , Suzhou , China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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