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Impaired Cytokine Production and Decreased TLR2-Mediated Signaling in Mouse Infant Macrophages.
MedLine Citation:
PMID:  22443189     Owner:  NLM     Status:  Publisher    
Infants are known to be more susceptible to pathogens. This might be due in part to the impaired function of macrophage. In the present study, we observed that macrophages from infant mice produced decreased levels of TNF-α and IL-6, but increased IL-10 after stimulation with toll-like receptor 2 (TLR2) agonist zymosan. Moreover, zymosan-stimulated activation of mitogen-activated protein kinase (MAPK) p38 and ERK1/2 was significantly reduced in mouse infant macrophages. These effects could be reversed by using MAPK modulators. The findings suggest that the impaired cytokine production and decreased TLR2-mediated signaling in infant macrophages may contribute to the susceptibility of infants to bacterial infection.
Guoji Zhu; Xuhua Ge; Jie Zhu; Yan Wei; Jian Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-23
Journal Detail:
Title:  Fetal and pediatric pathology     Volume:  -     ISSN:  1551-3823     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230972     Medline TA:  Fetal Pediatr Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Soochow University Affiliated Children's Hospital , Suzhou , China.
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