Document Detail


Impaired critical period plasticity in primary auditory cortex of fragile X model mice.
MedLine Citation:
PMID:  24089476     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fragile X syndrome, the most common form of heritable mental retardation, is a developmental disorder with known effects within sensory systems. Altered developmental plasticity has been reported in the visual and somatosensory systems in Fmr1 knock-out (KO) mice. Behavioral studies have revealed maladaptive auditory responses in fragile X syndrome patients and Fmr1 KO mice, suggesting that adaptive plasticity may also be impaired in the auditory system. Here we show that, whereas tonotopic frequency representation develops normally in Fmr1 KO mice, developmental plasticity in primary auditory cortex is grossly impaired. This deficit can be rescued by pharmacological blockade of mGluR5 receptors. These results support the mGluR hypothesis of fragile X mental retardation and suggest that deficient developmental plasticity may contribute to maladaptive auditory processing in fragile X syndrome.
Authors:
Heesoo Kim; Robert Gibboni; Colleen Kirkhart; Shaowen Bao
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  33     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-03     Completed Date:  2013-11-25     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15686-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Auditory Cortex / drug effects,  physiopathology*
Critical Period (Psychology)
Disease Models, Animal
Excitatory Amino Acid Antagonists / pharmacology
Fragile X Mental Retardation Protein / genetics
Fragile X Syndrome / physiopathology*
Mice
Mice, Knockout
Neuronal Plasticity / drug effects,  physiology*
Neurons / drug effects,  physiology*
Pyridines / pharmacology
Receptor, Metabotropic Glutamate 5 / antagonists & inhibitors
Grant Support
ID/Acronym/Agency:
DC009259/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/6-methyl-2-(phenylethynyl)pyridine; 0/Excitatory Amino Acid Antagonists; 0/Fmr1 protein, mouse; 0/Pyridines; 0/Receptor, Metabotropic Glutamate 5; 139135-51-6/Fragile X Mental Retardation Protein
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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