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Impaired Carbon Monoxide Diffusing Capacity is the Strongest Predictor of Exercise Intolerance in COPD.
MedLine Citation:
PMID:  23547629     Owner:  NLM     Status:  In-Data-Review    
Abstract Background: Exercise intolerance is a hallmark of chronic obstructive pulmonary disease (COPD) and forced expiratory volume in one second (FEV1) is the traditional metric used to define the severity of COPD. However, there is dissociation between FEV1 and exercise capacity in a large proportion of subjects with COPD. The aim of this study was to investigate whether other lung function parameters have an additive, predictive value for exercise capacity and whether this differs according to the COPD stage. Methods: Spirometry, body plethysmography and diffusing capacity for carbon monoxide (DLCO) were performed on 88 patients with COPD GOLD stages II-IV. Exercise capacity (EC) was determined in all subjects by symptom-limited, incremental cycle ergometer testing. Results: Significant relationships were found between EC and the majority of lung function parameters. DLCO, FEV1 and inspiratory capacity (IC) were found to be the best predictors of EC in a stepwise regression analysis explaining 72% of EC. These lung function parameters explained 76% of EC in GOLD II, 72% in GOLD III and 40% in GOLD IV. DLCO alone was the best predictor of exercise capacity in all GOLD stages. Conclusions: Diffusing capacity was the strongest predictor of exercise capacity in all subjects. In addition to FEV1, DLCO and IC provided a significantly higher predictive value regarding exercise capacity in COPD patients. This suggests that it is beneficial to add measurements of diffusing capacity and inspiratory capacity when clinically monitoring COPD patients.
Amir Farkhooy; Christer Janson; Rangheidur Harpa Arnardóttir; Andrei Malinovschi; Margareta Emtner; Hans Hedenström
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  COPD     Volume:  10     ISSN:  1541-2563     ISO Abbreviation:  COPD     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101211769     Medline TA:  COPD     Country:  England    
Other Details:
Languages:  eng     Pagination:  180-5     Citation Subset:  IM    
1Department of Medical Sciences: Clinical Physiology, Uppsala University , Uppsala , Sweden.
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