| Impacts of maternal selenium and nutritional level on growth, adiposity, and glucose tolerance in female offspring in sheep. | |
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MedLine Citation:
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PMID: 20920781 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To examine effects of maternal nutrition and Se intake on adiposity and insulin sensitivity in female offspring, treatments were imposed during gestation on 82 pregnant primiparous Rambouillet ewe lambs (52.2 ± 0.8 kg) allotted randomly to 1 of 6 treatments in a 2 × 3 factorial arrangement. Factors were adequate (9.5 μg Se·kg BW(-1)·d(-1); ASe) or high (81.8 μg Se·kg BW(-1)·d(-1); HSe) levels of dietary Se (Se-enriched yeast) and maternal nutritional intake (100% of metabolizable energy [ME] requirement [MOD], 60% of MOD [LOW], and 140% of MOD [HIGH]). Selenium treatments were initiated at breeding and global nutritional treatments at day 50 of gestation. At parturition, lambs were removed from ewes before nursing and managed similarly. Glucose tolerance tests were performed at 107 and 148 d of age. Necropsies were performed at 180 d of age. Although there was no effect of Se on maternal body condition or weight during gestation, both maternal nutritional intake and selenium treatment influenced (P ≤ 0.04) offspring growth and response to a glucose tolerance test. Female lambs from HSe ewes were heavier (P = 0.04) at birth. There were nutritional intake and Se interactions (P ≤ 0.05) on the growth rate of the lambs and their insulin response to a glucose bolus at 2 different times during growth. By 180 d, ewe lambs from HSe ewes had more (P ≤ 0.07) internal fat stores than lambs from ASe ewes. It appears that both maternal nutritional level and Se intake can influence insulin sensitivity, and maternal Se intake alone can enhance fat deposition in female offspring. |
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Authors:
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K A Vonnahme; J S Luther; L P Reynolds; C J Hammer; D B Carlson; D A Redmer; J S Caton |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-25 |
Journal Detail:
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Title: Domestic animal endocrinology Volume: 39 ISSN: 1879-0054 ISO Abbreviation: Domest. Anim. Endocrinol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-05 Completed Date: 2011-01-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505191 Medline TA: Domest Anim Endocrinol Country: United States |
Other Details:
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Languages: eng Pagination: 240-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, USA. Kim.Vonnahme@ndsu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity* Animals Body Composition Diet* Energy Intake Female Glucose Tolerance Test / veterinary* Insulin / blood Maternal Nutritional Physiological Phenomena Pregnancy Prenatal Exposure Delayed Effects / veterinary* Selenium / administration & dosage* Sheep / growth & development, metabolism, physiology* |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin; 7782-49-2/Selenium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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