Document Detail

Impact of vitamin A megadose supplementation on the anthropometry of children and adolescents with non-hormonal statural deficit: a double-blind and randomized clinical study.
MedLine Citation:
PMID:  12951904     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the intake of retinol and carotenoids, and their serum levels, as well as the impact of vitamin A supplementation on the anthropometry and body composition of children and adolescents with non-hormonal-related statural deficit. METHOD: Double-blind, randomized trial of 46 pre-pubertal patients, between 4 and 14 years of age, with normal growth rates. The subjects were divided into two groups, each with 23 individuals (Group I: Placebo; Group II: Vitamin A in a single megadose), and were evaluated at moments A and B with a six month interval. RESULTS: There were no statistically significant differences in serum retinol levels, anthropometry, growth velocity, or body composition, between moments A and B, in Group II. Carotenoids were significantly lower in Group I at moment B. The semi-quantitative food intake questionnaire showed that approximately 60.9% of the children and adolescents ingested less than half of the amounts of retinol and carotenoids recommended by the Food Guide Pyramid. Inadequate intake was more prevalent regarding vegetable and fruit carotenoid sources, with 75 and 70% of inadequacy, respectively. CONCLUSION: If one considers the inadequate food intake observed in the dietary evaluation in this study, it is possible that multiple micronutrient deficiencies could be involved in statural deficits. This could explain why vitamin A supplementation does not seem to influence growth in children and adolescents with statural deficit, as indicated by the present study. Thus in populations such as the one studied here, the supplementation with vitamin A should be integrated into comprehensive nutritional interventions, so as to possibly promote greater positive impact on linear growth.
Roseli Saccardo Sarni; Cristiane Kochi; Rejane Andrea Ramalho; Denise Oliveira Schoeps; Kazuê Sato; Lilian Mattoso; Cristiane Félix Ximenes Pessotti; Fabíola Isabel Suano Souza; Flavia Maria Damiani; Priscila Catherino
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition     Volume:  73     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-09-03     Completed Date:  2004-02-04     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  303-11     Citation Subset:  IM    
Discipline of Pediatrics of Faculty of Medicine, ABC Foundation, Santo Andre, Brazil.
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MeSH Terms
Body Composition / drug effects,  physiology
Carotenoids / administration & dosage,  blood
Child, Preschool
Dietary Supplements*
Dose-Response Relationship, Drug
Double-Blind Method
Growth Disorders / blood,  diet therapy*,  prevention & control*
Nutritional Status
Time Factors
Vitamin A / administration & dosage,  blood,  pharmacology*
Reg. No./Substance:
11103-57-4/Vitamin A; 36-88-4/Carotenoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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