Document Detail

Impact of vitamin D supplementation on markers of bone mineral metabolism in term infants.
MedLine Citation:
PMID:  22776138     Owner:  NLM     Status:  Publisher    
25-hydroxyvitamin D (25OHD) may influence bone turnover. We compared the dynamics of bone markers in 30 infants on vitamin D supplementation (≅550IU/d) with different degrees of hypovitaminosis D (25OHD <11ng/ml - deficiency vs. ≥11<20ng/ml - insufficiency). Baseline and follow-up (after 10weeks), 25OHD, 1,25-dihydroxyvitamin D (1,25(OH)(2)D), alkaline phosphatase (ALP), PTH, osteocalcin (OC), N-terminal propeptide of type I procollagen (PINP), C-terminal telopeptide of type I collagen (CTX), amino-terminal propeptide of C-type natriuretic peptide (NT-proCNP) were measured. None of the newborns had craniotabes, hypocalcaemia or hyperparathyroidism. The median (Q1;Q3) 25OHD increased from a baseline of 8.45 (7;11.9) ng/ml to 54.6 (34.7;67.3) ng/ml (p<0.001). The baseline 25OHD negatively correlated with total increment of 25OHD (r=-0.54; p=0.002). There were changes in ALP (241 vs. 331IU; p<0.001), 1,25(OH)(2)D (48 vs. 95.5pg/ml, p<0.001), OC (88.8 vs. 159.1ng/ml, p<0.001), PINP (3886 vs. 2409ng/ml; p<0.001), CTX (1.6 vs. 1.1ng/ml; p<0.001), NT-proCNP (75.1 vs. 35.1pmol/l; p<0.001). Vitamin D deficient infants at baseline, compared to the insufficient group, revealed significantly higher percentage changes for 25OHD (745% vs. 167%, p<0.0001), OC (113% vs. 40%, p<0.05) and 1,25(OH)(2)D (95% vs. 58%, p<0.05). Conclusions: Vitamin D supplements had little to no impact on markers of bone turnover in term infants in the first few months of life, with the exception of osteocalcin. Ten weeks of cholecalciferol supplementation at a dose of 550IU/d led to a marked increase of 25OHD concentration. The magnitude of 25OHD increment was inversely related to vitamin D status at baseline. Irrespective of the severity of vitamin D deficiency, a secondary hyperparathyroidism with elevated iPTH, ALP, phosphaturia or hypophosphatemia was not observed in the studied neonates.
Justyna Czech-Kowalska; Pawel Pludowski; Anna Dobrzanska; Edyta Kryskiewicz; Elzbieta Karczmarewicz; Dariusz Gruszfeld; Agata Pleskaczynska; Małgorzata Golkowska
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-6
Journal Detail:
Title:  Bone     Volume:  -     ISSN:  1873-2763     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8504048     Medline TA:  Bone     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Department of Neonatology and Neonatal Intensive Care, The Children's Memorial Health Institute, 04-730 Warsaw, Al. Dzieci Polskich 20, Poland.
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