Document Detail


Impact of visceral adipose tissue on liver metabolism. Part I: heterogeneity of adipose tissue and functional properties of visceral adipose tissue.
MedLine Citation:
PMID:  18550411     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Excess visceral adipose tissue is associated with anomalies of blood glucose homoeostasis, elevation of plasma triglycerides and low high-density lipoprotein cholesterol that contribute to the later appearance of type 2 diabetes and cardiovascular syndromes. Visceral adipose tissue releases a large amount of free fatty acids and hormones/cytokines in the portal vein that are delivered to the liver, and interact with hepatocytes and various immune cells in the liver. The functional characteristics of visceral adipose tissue will be compared with subcutaneous adipose tissue to clarify the major mechanisms affecting free fatty acid metabolism and cytokine production.
Authors:
M Lafontan; J Girard
Publication Detail:
Type:  Journal Article; Review     Date:  2008-06-11
Journal Detail:
Title:  Diabetes & metabolism     Volume:  34     ISSN:  1262-3636     ISO Abbreviation:  Diabetes Metab.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-22     Completed Date:  2008-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607599     Medline TA:  Diabetes Metab     Country:  France    
Other Details:
Languages:  eng     Pagination:  317-27     Citation Subset:  IM    
Affiliation:
Inserm-U858, institut de médecine moléculaire Rangueil, IFR31-institut Louis-Bugnard, 1, avenue Jean-Poulhès, B.P. 84225, 31432 Toulouse cedex 4, France. max.lafontan@toulouse.inserm.fr
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MeSH Terms
Descriptor/Qualifier:
Abdominal Fat / metabolism,  physiology
Adipocytes / cytology,  metabolism
Adipokines / metabolism
Diabetes Mellitus, Type 2 / etiology,  metabolism
Fatty Acids, Nonesterified / metabolism
Female
Glucose Intolerance / etiology,  physiopathology
Humans
Insulin Resistance / physiology
Intra-Abdominal Fat / cytology,  metabolism*
Liver / metabolism*,  physiology
Male
Obesity / complications,  metabolism
Subcutaneous Fat, Abdominal / cytology,  metabolism*
Chemical
Reg. No./Substance:
0/Adipokines; 0/Fatty Acids, Nonesterified

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