Document Detail

Impact of vascular remodeling on the coronary plaque compositions: an investigation with in vivo tissue characterization using integrated backscatter-intravascular ultrasound.
MedLine Citation:
PMID:  18606416     Owner:  NLM     Status:  MEDLINE    
Recent studies have indicated that positive remodeling is strongly associated with development of acute coronary syndrome (ACS). The aim of this study was to compare plaque composition of vascular remodeling patterns by an established in vivo tissue characterization method using integrated backscatter (IB)-intravascular ultrasound (IVUS). The study population consisted of 41 consecutive patients who received IVUS prior to percutaneous coronary intervention. Remodeling index (RI) was calculated as the external elastic membrane (EEM) area at the minimal lumen area (MLA) site divided by average EEM area at the proximal and distal reference sites. The patients were divided into two groups based on RI: positive remodeling (PR) defined as RI>1 and non-PR as RI<or=1. A total of 21 areas centered at MLA per lesion site were evaluated by IB-IVUS at 1mm intervals. The occupancy rate of four tissue types within atherosclerotic plaques was compared between the two groups. Percent lipid volume in the PR group (n=20) was significantly greater than the non-PR group (n=21) (40.5+/-14.8% vs. 26.4+/-15.9%, p<0.001). In contrast, % fibrous volume in the PR group was significantly lower than the non-PR group (49.9+/-9.4% vs. 56.1+/-9.6%, p=0.042). Percent dense fibrous volume and % calcified volume were slightly but significantly lower in the PR group compared with the non-PR group (dense fibrous: 6.8+/-5.0% vs. 11.6+/-8.4%, p=0.034, calcified: 2.6+/-2.0% vs. 5.1+/-4.4%, p=0.026). In conclusions, PR lesions contain more lipid-rich and less hard plaque components compared with non-PR lesions, which may account for the higher incidence of ACS and plaque vulnerability.
Hiroki Takeuchi; Yoshihiro Morino; Takashi Matsukage; Naoki Masuda; Yota Kawamura; Satoshi Kasai; Tadashi Hashida; Daisuke Fujibayashi; Teruhisa Tanabe; Yuji Ikari
Related Documents :
10525486 - Beta-particle-emitting radioactive stent implantation. a safety and feasibility study.
21331316 - Cardiorenal syndrome caused by heart failure with preserved ejection fraction.
15389236 - Rapamycin-eluting stents for the treatment of unprotected left main coronary disease.
17010786 - Vessel size and outcome after coronary drug-eluting stent placement: results from a lar...
7221676 - Subendocardial ischemia due to hypertension after induction of general anesthesia.
11153776 - Angioplasty increases coronary sinus f2-isoprostane formation: evidence for in vivo oxi...
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-06-05
Journal Detail:
Title:  Atherosclerosis     Volume:  202     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-26     Completed Date:  2009-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  476-82     Citation Subset:  IM    
Division of Cardiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Coronary Syndrome / pathology,  ultrasonography*
Angina Pectoris / pathology,  ultrasonography
Calcinosis / pathology,  ultrasonography*
Coronary Vessels / pathology,  ultrasonography*
Middle Aged
Severity of Illness Index
Ultrasonography, Interventional / methods*
Ventricular Remodeling*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Newly developed PPAR-alpha agonist (R)-K-13675 inhibits the secretion of inflammatory markers withou...
Next Document:  An accurate estimation of bone density improves the accuracy of subject-specific finite element mode...