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Impact of uveitis on the phenotype of patients with recent inflammatory back pain. Data from the DESIR cohort.
MedLine Citation:
PMID:  22354889     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To determine the prevalence of uveitis in patients with recent inflammatory back pain ( IBP) suggestive of spondyloarthritis (SpA), and to investigate the impact of uveitis on the overall features of these patients. METHODS: The DESIR cohort is a prospective, multicenter French cohort of patients with early IBP suggestive of SpA, including 708 patients.Uveitis was defined by an ophthalmological episode diagnosed as uveitis by an ophthalmologist, or history of medical diagnosis of uveitis given to the patient. Data on the baseline demographic characteristics, functional status and quality of life, imaging features, BMD, and blood tests were compared in patients with and without uveitis. Factors associated with the presence of uveitis were identified both by uni and multivariate analysis (logistic regression). RESULTS: The prevalence of uveitis at inclusion in the DESIR cohort was 8.5%. Uveitis occurred after the first symptoms of IBP in 45%. Presence of uveitis was significantly associated (univariate) with pain in cervical spine, infection preceding inflammatory disease, previous diagnosis of inflammatory bowel disease, SF36 (mental and physical health, relation), Achilles enthesitis, elevated leukocyte count, radiological hip involvement; but not with fulfilment of classification criteria, HLA-B27, BASDAI, BASFI, ASDAS, BMD. Stepwise multivariate analysis found an association between uveitis and : pain in cervical spine, infection preceding inflammatory disease, previous diagnosis of inflammatory bowel disease, physical health limitation of SF36 (p<0.05). CONCLUSION: In recent IBP suggestive of SpA, uveitis is associated with IBD and infection. This might suggest a role of environmental factors in the incidence of uveitis in SpA. © 2012 by the American College of Rheumatology.
Authors:
D Wendling; C Prati; C Demattei; C Miceli; J P Daures; M Dougados
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-21
Journal Detail:
Title:  Arthritis care & research     Volume:  -     ISSN:  2151-4658     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101518086     Medline TA:  Arthritis Care Res (Hoboken)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 by the American College of Rheumatology.
Affiliation:
Dept of Rheumatology, CHU de Besançon, and EA 4266, Université de Franche-Comté, Besançon, France. dwendling@chu-besancon.fr.
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