Document Detail


Impact of uraemia on food efficiency and the pulsatile mode of growth hormone secretion in rats.
MedLine Citation:
PMID:  7595147     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In view of the profound growth failure resulting from renal insufficiency and uraemia, the present studies were designed to specifically investigate food efficiency and the pattern of GH secretion under these conditions. Animals were made uraemic by 5/6 nephrectomy (Nx) and feeding a high-protein diet. Three groups of animals were studied: uraemic (Ur); sham-operated, fed ad libitum (Sh); and sham-operated pair-fed with the uraemics (PF). Food intake per 100 g body weight and food efficiency (g weight gained per g food consumed) were calculated. Fourteen days after 5/6 Nx, blood samples were taken via intra-atrial catheters at 10-min intervals over a period of 6 h. GH was measured in plasma by radioimmunoassay. GH pulsatility was analysed by multiple parameter deconvolution. The growth rate of Ur animals was significantly lower than that of Sh. The body weights of the Ur animals were also lower than PF due to an initial period of weight loss. Both Sh and PF animals showed the typical negative slope of food intake as body weight increased. In contrast, the Ur animals showed a positive slope of food intake. The lower rate of growth and the elevated food intake corresponded to a decreased food efficiency for the Ur group. Deconvolution analysis of pulsatile GH release demonstrated a significant increase in GH half-life in the Ur animals. The amplitude and mass of GH secretory pulses were decreased, whereas the number of detectable secretory bursts was increased. These changes were specific to uraemia with respect to half-life and number of pulses.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
R J Krieg; K Latta; K Niimi; J D Veldhuis; J C Chan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  146     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-11-27     Completed Date:  1995-11-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  509-17     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA.
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MeSH Terms
Descriptor/Qualifier:
Animal Nutritional Physiological Phenomena*
Animals
Energy Intake
Growth Hormone / secretion*
Male
Rats
Rats, Sprague-Dawley
Secretory Rate
Uremia / metabolism,  physiopathology*
Weight Gain
Grant Support
ID/Acronym/Agency:
DK07526/DK/NIDDK NIH HHS; DK24085/DK/NIDDK NIH HHS; DK31370/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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