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Impact of tumor cell kinetics on the outcome of induction chemotherapy in oral carcinoma patients.
MedLine Citation:
PMID:  21541568     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Pretherapeutic S-phase fractions of 68 carcinomas of the tongue and the floor of mouth were analysed by DNA flow cytometry immediately before intra-arterial induction chemotherapy with cisplatin and epirubicin or 5-fluorouracil. Patients with diploid tumors had an excellent 5-year survival rate of 89% in contrast to only 31% in the aneuploid group. Cell proliferation had no impact on the outcome of diploid cases. Node-positive patients with aneuploid tumors had a poor 18% 5-year survival rate, independent of S-phase fractions. Survival was significantly worse in nodenegative patients with high proliferating aneuploid tumors (45%) compared to the low-proliferative N-0 group (83%).
Authors:
J Hemmer; E Nagel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of oncology     Volume:  9     ISSN:  1019-6439     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  2011-05-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  679-83     Citation Subset:  -    
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