| Impact of transvascular and cellular-interstitial water exchange on dynamic contrast-enhanced magnetic resonance imaging estimates of blood to tissue transfer constant and blood plasma volume. | |
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MedLine Citation:
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PMID: 23197427 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To examine the effect of transvascular (k(be) ) and cellular-interstitial water protons exchange (k(ie) ) in estimates of the blood-to-tissue contrast agent transfer rate constant (K(trans) ), interstitial volume fraction (v(e) ), and blood plasma volume fraction (v(p) ) using a full three-site two exchange (3S2X) model. MATERIALS AND METHODS: Using the Bloch-McConnell equations, magnetic resonance imaging (MRI) signal arising from a 3S2X system was derived for the T(1) -weighted spoiled gradient-recalled echo (SPGR) pulse sequence. To model the effects of k(be) and k(ie) on estimates of R(1) , the MRI-measured arterial input function, the different sets of values of kinetic parameters: K(trans) , v(e) , and v(p) and water protons exchange rates, k(be) and k(ie) , were used. To calculate the tissue water protons R(1) , the signal evolving from a 3S2X model was set to a monoexponential function. By comparing the estimated K(trans) , v(e) , and v(p) with their simulated model truth values, the impact of k(be) and k(ie) on K(trans) , v(e) , and v(p) was evaluated. RESULTS: v(p) was strongly underestimated and K(trans) and v(e) were much less influenced by k(be) , when k(ie) was held constant. When k(be) was held constant, the k(ie) had a significant effect on K(trans) and v(e) and less effect on v(p) . CONCLUSION: The full 3S2X model allows accurate estimation of K(trans) , v(e) , and v(p) and rates of water proton exchange. J. Magn. Reson. Imaging 2012. © 2012 Wiley Periodicals, Inc. |
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Authors:
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Ramesh Paudyal; Harish Poptani; Kejia Cai; Rong Zhou; Jerry D Glickson |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-29 |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: - ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Department of Radiology, Molecular Imaging Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Ramesh.Paudyal@uphs.upenn.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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