Document Detail

Impact of transvascular and cellular-interstitial water exchange on dynamic contrast-enhanced magnetic resonance imaging estimates of blood to tissue transfer constant and blood plasma volume.
MedLine Citation:
PMID:  23197427     Owner:  NLM     Status:  Publisher    
PURPOSE: To examine the effect of transvascular (k(be) ) and cellular-interstitial water protons exchange (k(ie) ) in estimates of the blood-to-tissue contrast agent transfer rate constant (K(trans) ), interstitial volume fraction (v(e) ), and blood plasma volume fraction (v(p) ) using a full three-site two exchange (3S2X) model. MATERIALS AND METHODS: Using the Bloch-McConnell equations, magnetic resonance imaging (MRI) signal arising from a 3S2X system was derived for the T(1) -weighted spoiled gradient-recalled echo (SPGR) pulse sequence. To model the effects of k(be) and k(ie) on estimates of R(1) , the MRI-measured arterial input function, the different sets of values of kinetic parameters: K(trans) , v(e) , and v(p) and water protons exchange rates, k(be) and k(ie) , were used. To calculate the tissue water protons R(1) , the signal evolving from a 3S2X model was set to a monoexponential function. By comparing the estimated K(trans) , v(e) , and v(p) with their simulated model truth values, the impact of k(be) and k(ie) on K(trans) , v(e) , and v(p) was evaluated. RESULTS: v(p) was strongly underestimated and K(trans) and v(e) were much less influenced by k(be) , when k(ie) was held constant. When k(be) was held constant, the k(ie) had a significant effect on K(trans) and v(e) and less effect on v(p) . CONCLUSION: The full 3S2X model allows accurate estimation of K(trans) , v(e) , and v(p) and rates of water proton exchange. J. Magn. Reson. Imaging 2012. © 2012 Wiley Periodicals, Inc.
Ramesh Paudyal; Harish Poptani; Kejia Cai; Rong Zhou; Jerry D Glickson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-29
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  -     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Department of Radiology, Molecular Imaging Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
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