| Impact of a transfusion-related acute lung injury reduction strategy on apheresis platelet collections. | |
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MedLine Citation:
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PMID: 22535678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Most blood centers in the US have implemented transfusion-related acute lung injury (TRALI) mitigation strategies for apheresis platelet (AP) donations based on theoretical impact of donor loss. The aim of this study is to determine the actual impact of a TRALI mitigation strategy in a US blood center. STUDY DESIGN AND METHODS: Daily collection events and resulting products were retrospectively obtained before and after implementation of a TRALI reduction strategy (HLA antibody testing female AP donors four or more pregnancies) for comparison. The retention rate of reassigned donors was determined by reviewing whole blood (WB) and/or apheresis red blood cell (AR) donations post reassignment. Data were obtained to compare donor frequency and split rate from reassigned (historical data) and new AP donors. RESULTS: Mean daily collections (27.7 vs. 30.0) and total products (12,211 vs. 12,957) were significantly higher after implementation, but the number of products/collection event was lower (1.49 vs. 1.40). Mean collections/donor/year (4.0 vs. 1.8) and split rate (36% vs. 27%) were historically higher for reassigned (n = 45) versus new AP donors (n = 1,090). Seventy-three of 112 donors (65%) testing positive for HLA antibodies returned for WB or AR donations, 31 of 45 (69%) active AP donors returned. CONCLUSIONS: Donor loss may not be adequate to estimate impact on AP inventory, as donation characteristics may differ between new donors and those reassigned. We show successful implementation of a TRALI mitigation strategy by increasing collection goals and AP donor recruitment efforts beyond donor loss. Retaining the majority of reassigned donors is feasible. |
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Authors:
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Dennis Williams; Marepalli Rao; Patricia Carey |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-04-26 |
Journal Detail:
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Title: Journal of clinical apheresis Volume: 27 ISSN: 1098-1101 ISO Abbreviation: J Clin Apher Publication Date: 2012 |
Date Detail:
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Created Date: 2012-08-06 Completed Date: 2013-01-11 Revised Date: 2013-04-26 |
Medline Journal Info:
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Nlm Unique ID: 8216305 Medline TA: J Clin Apher Country: United States |
Other Details:
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Languages: eng Pagination: 205-11 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Department of Pathology and Laboratory Medicine, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA. djwi225@uky.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Lung Injury
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blood,
etiology*,
prevention & control* Blood Component Removal Blood Donors Blood Transfusion / adverse effects* Erythrocyte Transfusion Female HLA Antigens / blood Humans Isoantibodies / blood Ohio Parity / immunology Plasma / immunology Plateletpheresis* Pregnancy Retrospective Studies |
| Grant Support | |
ID/Acronym/Agency:
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UL1 TR000077/TR/NCATS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens; 0/Isoantibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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