Document Detail

Impact of a transfusion-related acute lung injury reduction strategy on apheresis platelet collections.
MedLine Citation:
PMID:  22535678     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Most blood centers in the US have implemented transfusion-related acute lung injury (TRALI) mitigation strategies for apheresis platelet (AP) donations based on theoretical impact of donor loss. The aim of this study is to determine the actual impact of a TRALI mitigation strategy in a US blood center.
STUDY DESIGN AND METHODS: Daily collection events and resulting products were retrospectively obtained before and after implementation of a TRALI reduction strategy (HLA antibody testing female AP donors four or more pregnancies) for comparison. The retention rate of reassigned donors was determined by reviewing whole blood (WB) and/or apheresis red blood cell (AR) donations post reassignment. Data were obtained to compare donor frequency and split rate from reassigned (historical data) and new AP donors.
RESULTS: Mean daily collections (27.7 vs. 30.0) and total products (12,211 vs. 12,957) were significantly higher after implementation, but the number of products/collection event was lower (1.49 vs. 1.40). Mean collections/donor/year (4.0 vs. 1.8) and split rate (36% vs. 27%) were historically higher for reassigned (n = 45) versus new AP donors (n = 1,090). Seventy-three of 112 donors (65%) testing positive for HLA antibodies returned for WB or AR donations, 31 of 45 (69%) active AP donors returned.
CONCLUSIONS: Donor loss may not be adequate to estimate impact on AP inventory, as donation characteristics may differ between new donors and those reassigned. We show successful implementation of a TRALI mitigation strategy by increasing collection goals and AP donor recruitment efforts beyond donor loss. Retaining the majority of reassigned donors is feasible.
Dennis Williams; Marepalli Rao; Patricia Carey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-04-26
Journal Detail:
Title:  Journal of clinical apheresis     Volume:  27     ISSN:  1098-1101     ISO Abbreviation:  J Clin Apher     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-06     Completed Date:  2013-01-11     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  8216305     Medline TA:  J Clin Apher     Country:  United States    
Other Details:
Languages:  eng     Pagination:  205-11     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Acute Lung Injury / blood,  etiology*,  prevention & control*
Blood Component Removal
Blood Donors
Blood Transfusion / adverse effects*
Erythrocyte Transfusion
HLA Antigens / blood
Isoantibodies / blood
Parity / immunology
Plasma / immunology
Retrospective Studies
Grant Support
Reg. No./Substance:
0/HLA Antigens; 0/Isoantibodies

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