| Impact of transfusion guidelines on neonatal transfusions. | |
| | |
MedLine Citation:
|
PMID: 9605296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Preterm infants with birth weights (BW) <1250 gm are given multiple blood transfusions either for replacement of blood loss or for correction of symptomatic anemia of prematurity. OBJECTIVE: To assess the effectiveness of transfusion guidelines in reducing the number of transfusions given to infants with BW <1250 gm. METHODS: This cohort study was conducted at the regional teaching medical center with level III obstetric and neonatal services. Preterm infants with BW <1250 gm and gestational age <32 weeks were admitted to the neonatal intensive care unit during a period of 6 months before and after implementation of transfusion guidelines. The final sample size constituted 39 infants before guidelines (BG) and 41 infants after guidelines (AG). The primary outcome measure was the total number and volume of transfusions given per infant in the first 2 weeks of life and before discharge from the nursery. RESULTS: We observed a significant reduction in the mean number (4.7 to 2.7, p = 0.003) and volume (52 ml to 30 ml, p = 0.0005) of transfusions given per infant in the first 2 weeks of life, as well as a definite trend toward reduction in the total number (10.5 to 8.0, p = 0.08) and volume (156 ml to 119 ml, p = 0.07) of transfusions given before discharge in the BG versus AG, respectively. When all the transfusions given to the 41 infants in the AG group were analyzed for compliance with guidelines, 96% (313 of 328) were observed to be in compliance. CONCLUSION: This study shows that transfusion guidelines are effective in decreasing the number of transfusion given to infants with BW <1250 gm. An indirect benefit of guidelines contributing to a reduced number of transfusions may be a heightened awareness to decrease blood losses. |
| | |
Authors:
|
A Alagappan; K E Shattuck; M H Malloy |
Related Documents
:
|
21398326 - Sudden, unexpected and unexplained early neonatal deaths in the north of england. 2605126 - Red cell glycolytic intermediates in normal, anaemic and transfused human fetuses. 16222346 - Effect of hematocrit on exhaled carbon monoxide in healthy newborn infants. 781206 - The role of exchange transfusions in the management of low-birth-weight infants with an... 8713736 - Pulsatile release of oxytocin in newborn infants. 3107866 - Digital swelling following long-term administration of prostaglandin e1 in an infant. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 18 ISSN: 0743-8346 ISO Abbreviation: J Perinatol Publication Date: 1998 Mar-Apr |
Date Detail:
|
Created Date: 1998-07-31 Completed Date: 1998-07-31 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 92-7 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, University of Texas Medical Branch, Galveston 77555-0526, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Transfusion* Cohort Studies Female Gestational Age Humans Infant, Low Birth Weight Infant, Newborn Infant, Premature, Diseases / blood, therapy* Male Practice Guidelines as Topic* Treatment Outcome Unnecessary Procedures |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Del(14)(q22.1q23.2) in a patient with anophthalmia and pituitary hypoplasia.
Next Document: Role of renal ultrasonography in the management of pyelonephritis in pregnant women.