Document Detail

Impact of transcatheter occlusion of a patent ductus arteriosus on atrial septal defect diameter in children.
MedLine Citation:
PMID:  18377555     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A persistent patent ductus arteriosus (PDA) may delay closure of a coexisting atrial septal defect (ASD) due to volume loading and enlargement of the left atrium. The purpose of this study was to investigate the natural history of ASD size in patients with a PDA following transcatheter PDA occlusion. METHODS: All patients with an ASD and a PDA who underwent transcatheter PDA occlusion at Texas Children's Hospital were identified. Patients with ASD diameter <3 mm, or additional cardiac defects were excluded. Eight patients (7 females) with small- to moderate-sized ASDs and a PDA were identified. Patient demographics, echocardiographic data, and cardiac catheterization data were recorded. Data were analyzed by 1-tailed t-test. RESULTS: Following PDA occlusion, ASD diameter decreased in 6 of 8 patients by a mean of 3.8 mm (+/-2.3 mm), including 2 that closed. The median duration of follow-up was 689 days. One ASD remained unchanged and 1 increased in size. The mean maximum ASD diameter decreased from 6.4 mm (+/-2.2 mm) to 3.9 mm (+/-3.4 mm) (P = .03). Two patients underwent subsequent transcatheter ASD occlusion. CONCLUSION: Following transcatheter PDA occlusion, small- to moderate-sized ASDs have significant probability to decrease in size, and possibly close. In infants and children, we recommend transcatheter PDA occlusion, and serial follow-up of the size of the ASD. This will allow many small- to moderate-sized ASDs to either close, or become smaller, obviating the need for future intervention.
Gary E Stapleton; Benjamin W Eidem; Ricardo H Pignatelli; Karina M Carlson; Charles E Mullins; Ronald G Grifka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Congenital heart disease     Volume:  1     ISSN:  1747-0803     ISO Abbreviation:  -     Publication Date:  2006 May 
Date Detail:
Created Date:  2008-04-01     Completed Date:  2008-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256510     Medline TA:  Congenit Heart Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  116-9     Citation Subset:  IM    
Department of Pediatrics, Section of Pediatric Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
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MeSH Terms
Blood Vessel Prosthesis Implantation*
Child, Preschool
Ductus Arteriosus, Patent / complications*,  surgery*
Heart Catheterization
Heart Septal Defects, Atrial / complications*,  diagnosis,  physiopathology*
Infant, Newborn
Retrospective Studies
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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