Document Detail

Impact of tracheal mucosa involvement on clinical characteristics of sarcoidosis.
MedLine Citation:
PMID:  21606707     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES: : To investigate the impact of tracheal mucosa involvement on the clinical features of sarcoidosis.
METHODS: : The clinical data of sarcoidosis patients with (Group A, n = 26) and without (Group B, n = 61) tracheal mucosa involvement were evaluated retrospectively.
RESULTS: : The proportion of patients suffering from cough in Group A was 92.3%, which was significantly higher than that in Group B (49.2%). The level of serum angiotensin-converting enzyme I (SACE) in Group A (60.7 ± 27.8 IU/L) was significantly higher than that in Group B (44.5 ± 31.9 IU/L). The proportion of lymphocytes in the bronchoalveolar lavage fluid (BALF) in Group A was significantly higher than that of Group B (45.3 ± 16.8% and 36.7 ± 15.1%, respectively; P = 0.047). The ratio of CD4 to CD8 in Group A was significantly higher than that in Group B (7.6 ± 5.4 and 3.1 ± 3.2, respectively; P = 0.005). In Group A, 84.6% patients received drug treatment, with a spontaneous remission rate of 15.4%. In Group B, 50.2% patients received drug treatment and the spontaneous remission rate was as high as 49.2%.
CONCLUSIONS: : Sarcoidosis with tracheal mucosa involvement that can lead to cough and other respiratory symptoms, may be a manifestation of sarcoidosis activity, and usually requires drug treatment (including corticosteroid treatment).
Ding Xin-Min; Xu Qin-Zhi; Duan Yun-You; Zhang Chun-Yan; Pen Chao-Sheng; Ning Hao-Yong; Li Yong-Qun; Meng Ji-Guang; Nie Zhou-Shan; Feng Hua-Song
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  104     ISSN:  1541-8243     ISO Abbreviation:  South. Med. J.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  315-8     Citation Subset:  AIM; IM    
From the Department of Respiratory Medicine, Sarcoidosis Treatment Center of PLA, Navy General Hospital of PLA; and Beijing Institute of Radiation Medicine, Beijing City, China.
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