| Impact of systemic and local peritoneal inflammation on peritoneal solute transport rate in new peritoneal dialysis patients: a 1-year prospective study. | |
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MedLine Citation:
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PMID: 20100731 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The association between peritoneal solute transport rates (PSTRs) and inflammatory markers in patients on peritoneal dialysis (PD) is still under investigation. We aimed to elucidate their relationship during the first year on PD. METHODS: We performed a prospective observational study with 187 incident PD patients who were treated with either biocompatible solution (BCS) or conventional solution (CS). Peritoneal dialysate effluent (PDE) and blood samples for the markers and the calculation of mass transfer area coefficient of creatinine (MTAC) were performed at 1, 6 and 12 months after commencing PD. RESULTS: Of the 187 enrolled patients, 110 completed a 1-year study protocol. All PDE markers [interleukin-6 (IL-6), transforming growth factor-beta (TGF-beta), TGF-beta-induced gene-h3 (beta ig-h3), vascular endothelial growth factor (VEGF)] except CA125 increased over time, whereas PSTRs, high-sensitivity C-reactive protein (hs-CRP) and serum IL-6 levels did not change. Serum albumin and log PDE appearance rates (ARs) of IL-6, TGF-beta and CA125 predicted MTAC. The Delta value (12-month minus 1-month) of PDE AR of IL-6 was correlated with those of all other PDE markers. Both 12-month IL-6 and Delta IL-6 ARs in PDE were highest in the upper Delta MTAC tertile. PSTRs in the CS group, unlike BCS, had a tendency to increase over time, demonstrating a time-by-group interaction. Solution type and MTAC were not associated with patient and technique survival. CONCLUSIONS: The change in PSTR during the first year of PD is related to PDE IL-6 AR, which may represent intraperitoneal inflammation; however, there does not seem to be a close association between PSTR and the degree of systemic inflammation. |
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Authors:
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Ji-Hyung Cho; In-Kyong Hur; Chan-Duck Kim; Sun-Hee Park; Hye-Myung Ryu; Ju-Min Yook; Ji-Young Choi; Hee-Jung Choi; Hyuk-Joon Choi; Jong-Won Park; Jun-Young Do; Yong-Lim Kim |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-25 |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 25 ISSN: 1460-2385 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-26 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England |
Other Details:
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Languages: eng Pagination: 1964-73 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biological Markers / analysis, blood Biological Transport, Active CA-125 Antigen / analysis, blood Creatinine / analysis, blood Cytokines / analysis, blood Dialysis Solutions Female Humans Inflammation / physiopathology* Inflammation Mediators / analysis, blood Interleukin-6 / analysis, blood Kaplan-Meiers Estimate Kidney Failure, Chronic / physiopathology, therapy Male Membrane Proteins / analysis, blood Middle Aged Peritoneal Dialysis / adverse effects* Peritoneum / physiopathology* Peritonitis / physiopathology* Permeability Prospective Studies Transforming Growth Factor beta / analysis, blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/CA-125 Antigen; 0/Cytokines; 0/Dialysis Solutions; 0/IL6 protein, human; 0/Inflammation Mediators; 0/Interleukin-6; 0/MUC16 protein, human; 0/Membrane Proteins; 0/Transforming Growth Factor beta; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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