| Impact of systemic hypertension on the diagnostic performance of B-type natriuretic peptide in patients with acute dyspnea. | |
| | |
MedLine Citation:
|
PMID: 19766765 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hypertension may affect the diagnostic performance of B-type natriuretic peptide (BNP). The objective of the present study was to assess the impact of a history of hypertension or blood pressure elevation on admission on the diagnostic performance of BNP in the diagnosis of heart failure (HF) in patients with acute dyspnea. BNP levels were measured using a rapid point-of-care device in 1,586 patients with acute dyspnea. In patients with HF, BNP levels did not differ between those with and without histories of hypertension. Conversely, in patients without HF, a history of hypertension was associated with higher median BNP levels (38 pg/ml [interquartile range 13 to 119] vs 21 pg/ml [interquartile range 7 to 64], p <0.001). The areas under the receiver-operating characteristic curves were 0.88 and 0.93 for those with and without histories of hypertension, respectively (p <0.001). Blood pressure elevation on admission did not affect the diagnostic accuracy of BNP (areas under the curve 0.90 in the 2 groups). In conclusion, although a history of hypertension is associated with higher BNP levels in patients with acute dyspnea without HF, the impact on the overall diagnostic performance of BNP is modest. Accordingly, BNP performs well as an indicator of HF in patients presenting in emergency departments regardless of a history of hypertension or elevated blood pressure on admission. |
| | |
Authors:
|
Andreas S Pahle; Daniel Sørli; Torbjørn Omland; Cathrine Wold Knudsen; Arne Westheim; Alan H B Wu; Philippe Gabriel Steg; James McCord; Richard M Nowak; Judd E Hollander; Alan B Storrow; William T Abraham; Peter A McCullough; Alan Maisel |
Related Documents
:
|
2318225 - Haemodynamics of induced atrial fibrillation: a comparative assessment with sinus rhyth... 1258735 - Systolic time intervals in induced atrial fibrillation in the dog. 7976415 - Intrinsic cardiac rate regulation in the anaesthetized rabbit. 17444305 - The cardiovascular effects of adrenaline, dobutamine and milrinone in rabbits using pre... 16376355 - Ultrahigh pressure liquid chromatography using elevated temperature. 650775 - Impotence: a diagnostic approach. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of cardiology Volume: 104 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-09-21 Completed Date: 2009-10-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 966-71 Citation Subset: AIM; IM |
Affiliation:
|
Division of Medicine, Akershus University Hospital, Lørenskog, Norway. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Aged Biological Markers / blood, metabolism Blood Pressure Determination Cohort Studies Confidence Intervals Dyspnea / blood, diagnosis*, etiology, therapy Emergency Service, Hospital Female Heart Failure / blood, complications, diagnosis* Humans Hypertension / blood, complications, diagnosis* Male Middle Aged Natriuretic Peptide, Brain / blood*, metabolism Predictive Value of Tests Probability ROC Curve Sensitivity and Specificity Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association of the Parameters Derived From the Relation Between RR Intervals and Left Ventricle Perf...
Next Document: Meta-analysis of prognostic value of stress testing in patients with asymptomatic severe aortic sten...