Document Detail


Impact of systemic blood pressure on the relationship between intraocular pressure and blood flow in the optic nerve head of nonhuman primates.
MedLine Citation:
PMID:  19074806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Studies suggest that reduced ocular perfusion pressure in the optic nerve head (ONH) increases the risk of glaucoma. This study tested a hypothesis that the magnitude of blood flow change in the ONH induced between two same intraocular pressure (IOP) alterations depends on the level of mean systemic blood pressure (BP). METHODS: In eight anesthetized rhesus monkeys, systemic BP was maintained at either a high, medium, or low level (n = 6 each, ranging from 51-113 mm Hg); IOP was rapidly altered from 10 to 30 mm Hg and then to 10 mm Hg manometrically. Blood flow in the ONH (BF(ONH)) was repeatedly measured with a laser speckle flow graph for 10 minutes at each IOP level period. The BF(ONH) and relative changes to the baselines at each measured time point were calculated and compared longitudinally among the three BP groups. RESULTS: There was no statistically significant difference in mean baseline BF(ONH) across the BP groups. In the high-BP group, BF(ONH) had no significant change during the IOP alterations. However, the same IOP alterations caused a significant BF(ONH) change in the two lower BP groups. The duration of the BF(ONH) changes from baseline to a peak and to a steady state was significantly delayed in the two lower, but not the higher, BP groups. CONCLUSIONS: Systemic BP plays an important role in maintaining the normal autoregulation of the ONH, and it became deficient in the lower BP groups. In patients with glaucoma, a normal, sustained BP may be important to prevent worsening glaucoma.
Authors:
Yi Liang; J Crawford Downs; Brad Fortune; Grant Cull; George A Cioffi; Lin Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-13
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  50     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-23     Completed Date:  2009-05-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2154-60     Citation Subset:  IM    
Affiliation:
Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Health System, Portland, Oregon 97232, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity
Blood Pressure / physiology*
Female
Intraocular Pressure / physiology*
Laser-Doppler Flowmetry
Macaca mulatta
Male
Optic Disk / blood supply*
Regional Blood Flow / physiology
Reproducibility of Results

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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