| Impact of shear stress on early vein graft remodeling: a biomechanical analysis. | |
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MedLine Citation:
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PMID: 15636109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, an analytical technique was developed to estimate the dynamic, three-dimensional wall shear and tensile forces within the arterial circulation and applied to our established model of flow-mediated graft remodeling within the rabbit carotid system. Through selective unilateral distal ligation, vein grafts were exposed to distinct flow environments, characterized by a sixfold difference in mean flow rate. Implanted vein grafts were harvested at 1, 3, 7, 14, and 28 days to evaluate graft morphology. Hemodynamic and real-time imaging data, obtained at graft implantation and harvest, served as input for estimation of dynamic shear stress and wall tension. Marked differences in the remodeling process were observed in high vs. low flow grafts, with low flow grafts demonstrating accelerated intimal hyperplasia and reduced outward remodeling. The impact was a peak in the maximum and minimum shear stress at Day 7, with a delayed increase in lumen diameter leading to partial normalization of the wall shear by Day 28. Intramural wall tension reached a maximum at Day 3, with an increase in wall thickness leading to a significant reduction in these forces by Day 14. Despite the significant morphologic changes, no differences in the incremental moduli of elasticity were observed. |
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Authors:
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Chessy M Fernandez; Darin R Goldman; Zhihua Jiang; C Keith Ozaki; Roger Tran-Son-Tay; Scott A Berceli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of biomedical engineering Volume: 32 ISSN: 0090-6964 ISO Abbreviation: Ann Biomed Eng Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2005-01-07 Completed Date: 2005-04-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 1484-93 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity Blood Vessel Prosthesis* Carotid Arteries* Male Models, Cardiovascular* Rabbits Stress, Mechanical |
| Grant Support | |
ID/Acronym/Agency:
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1K08-HL04070-01A1/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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