Document Detail

Impact of sex and hormones on new cells in the developing rat hippocampus: a novel source of sex dimorphism?
MedLine Citation:
PMID:  18333959     Owner:  NLM     Status:  MEDLINE    
The hippocampus is a key brain region regulating complex cognitive and emotional responses, and is implicated in the etiology of depressive and anxiety disorders, many of which exhibit some degree of sex difference. The male rat hippocampus is consistently reported to be slightly but significantly larger than the female. The majority of studies on the development of volumetric sex differences have focused on the effects of estradiol (E2), with relatively few focusing on androgens. We examined the impact of both E2 and androgens on newly born cells in the developing rat hippocampus, and report that neonatal males have significantly more 5-bromo-2'-deoxyuridine-5'-monophosphate (BrdU)+ cells than females. Both testosterone (T) and dihydrotestosterone treatment of females significantly increased the number of BrdU+ cells, an effect blocked by the androgen receptor antagonist, flutamide. However, only T significantly increased the number of neuronal nuclear antigen+ neurons in the female rat hippocampus. Interestingly, E2 treatment also increased BrdU+ cells in females, but had no effect on neuron number. Instead, E2 and T significantly increased the number of newly born glial fibrillary acidic protein or glutamine synthetase+ glial cells in females, indicating that androgens and E2 may act independently to achieve distinct endpoints. Quantification of pyknotic cells at two different developmental time points indicates no sex difference in the number of cells dying, suggesting, but not proving, that gonadal steroids are promoting cell genesis.
Jian-Min Zhang; Anne T M Konkle; Susan L Zup; Margaret M McCarthy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  27     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-03-12     Completed Date:  2008-07-08     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  791-800     Citation Subset:  IM    
Department of Psychiatry, University of Maryland, Baltimore, School of Medicine, Baltimore, MD 21201, USA.
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MeSH Terms
Androgens / pharmacology*
Cell Count
Cell Proliferation
Estradiol / pharmacology*
Glial Fibrillary Acidic Protein / metabolism
Hippocampus / drug effects,  growth & development*,  physiology
Neuroglia / cytology,  drug effects*,  physiology
Neurons / cytology,  drug effects*,  physiology
Rats, Sprague-Dawley
Sex Characteristics*
Grant Support
R01 NS050525-02/NS/NINDS NIH HHS; R01 NS050525-03/NS/NINDS NIH HHS
Reg. No./Substance:
0/Androgens; 0/Glial Fibrillary Acidic Protein; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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