Document Detail

Impact of the severity of end-stage liver disease in cardiac structure and function.
MedLine Citation:
PMID:  23293198     Owner:  NLM     Status:  In-Data-Review    
Background. The impact of end-stage liver disease (ESLD) in cardiac remodeling of patients with cirrhosis is unknown. Our aim was to correlate the severity of ESLD with morphologic and functional heart changes. Material and methods. 184 patients underwent a protocol providing data on the severity of ESLD and undergoing echocardiography to assess the diameters of the left atrium and right ventricle; the systolic and diastolic diameters of the left ventricle, interventricular septum, and posterior wall of the left ventricle; systolic pulmonary artery pressure; ejection fraction; and diastolic function. Severity of ESLD was assessed by the Model for End-Stage Liver Disease (MELD) score. Results. Left-atrial diameter (r = 0.323; IC 95% 0.190-0.455; p < 0.001), left-ventricular diastolic diameter (r = 0.177; IC 95% 0.033-0.320; p = 0.01) and systolic pulmonary artery pressure (r = 0.185; IC 95% 0.036-0.335; p = 0.02) significantly correlated with MELD score. Patients with MELD ≥ 16 had significantly higher left-atrial diameter and systolic pulmonary artery pressure, compared with patients with MELD scores < 16 points. Conclusions. Changes in cardiac structure and function correlate with the severity of ESLD.
Odilson Marcos Silvestre; Fernando Bacal; Danusa de Souza Ramos; Jose L Andrade; Meive Furtado; Vincenzo Pugliese; Elisangela Belleti; Wellington Andraus; Flair José Carrilho; Luiz Augusto Carneiro D'Albuquerque; Alberto Queiroz Farias
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of hepatology     Volume:  12     ISSN:  1665-2681     ISO Abbreviation:  Ann Hepatol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101155885     Medline TA:  Ann Hepatol     Country:  Mexico    
Other Details:
Languages:  eng     Pagination:  85-91     Citation Subset:  IM    
Heart Institute, University of Sao Paulo School of Medicine. Brazil.
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