Document Detail

Impact of sentinel node biopsy on long-term quality of life in breast cancer patients.
MedLine Citation:
PMID:  24169352     Owner:  NLM     Status:  Publisher    
Background:The aim of this study was to assess long-term quality of life (QoL) over a period of 6 years in women with breast cancer (BC) who underwent sentinel lymph node biopsy (SLNB), axillary lymph node dissection (ALND), or SLNB followed by ALND.Methods:The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ)-C30 and the EORTC-QLQ-BR-23 questionnaires were used to assess QoL before surgery, just after surgery, 6, 12 and 72 months later. The longitudinal effect of surgical modalities on QoL was assessed with a mixed model analysis of variance for repeated measurements.Results:Five hundred and eighteen BC patients were initially included. The median follow-up was 6 years. During the follow-up, 61 patients died. None of the patients of the SLNB group developed lymphedema during follow-up and the relapse rate was similar in the different groups (P=0.62). Before surgery, global health status (P=0.52) and arm symptoms (BRAS) (P=0.99) QoL scores were similar whatever the surgical procedure. The BRAS score (P=0.0001) was better in the SLNB group 72 months after surgery. Moreover, during follow-up, patients treated with SLNB had lower arm symptoms scores than ALND patients and there was no difference for arm symptoms between patients treated with ALND and those treated with SLNB followed by complementary ALND.Conclusion:Long-term follow-up showed that SLNB was associated with less morbidity than ALND.British Journal of Cancer advance online publication, 29 October 2013; doi:10.1038/bjc.2013.658
E De Gournay; A Guyomard; C Coutant; S Boulet; P Arveux; S Causeret; S Gouy; M-M Padeano; C Loustalot; J-M Sauzedde; M Smail; J-P Combier; P Chevillote; C Rosburger; F Bonnetain; J Fraisse; T S Dabakuyo-Yonli
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-29
Journal Detail:
Title:  British journal of cancer     Volume:  -     ISSN:  1532-1827     ISO Abbreviation:  Br. J. Cancer     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370635     Medline TA:  Br J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of surgery/Georges François Leclerc Comprehensive Cancer Care Centre-1 rue Professeur Marion, 21000 Dijon, France.
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