Document Detail


Impact of rotavirus infections on outpatient clinic visits in chile.
MedLine Citation:
PMID:  17195704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Incorporation of new rotavirus vaccines into national programs of developing countries will rely on well-designed cost-effective analysis based on accurate assessment of disease burden. For Chile, rotavirus disease burden is determined mostly by outpatient clinic and emergency room visits and by hospitalizations. We previously estimated a yearly incidence of 8000 and 53,000 hospitalizations and emergency room visits respectively for children <or=3 years of age. OBJECTIVE: The objective of this study was to quantify the impact of rotavirus as a cause of outpatient clinic visits. METHODS: A prospective surveillance protocol between the Health Ministry and the University of Chile in 11 outpatient clinics from 6 regions included reporting of all acute diarrhea cases in children <5 years of age and collection of a stool sample for the first 5 children per week. RESULTS: A total of 5217 acute diarrhea episodes requiring an outpatient medical visit for a total assigned population of 41,927 children <5 years of age were reported from August 1, 2004, to October 30, 2005, in the 11 clinics. A total of 179 rotavirus positive samples were detected from 1313 stools collected for an overall positivity of 13.6% (95% confidence limit: 11.8-15.6%). Rotavirus outpatient visits occurred during all 15 months without a clear seasonal predominance and peaked between 6 months and 2 years of age. G4 types predominated during the 15-month period. CONCLUSIONS: For Chilean children </=3 years of age, a yearly estimate of 11,658 to 16,305 outpatient medical visits need to be added to previous disease burden estimates.
Authors:
Miguel O'Ryan; Janepsy Díaz; Nora Mamani; Marisol Navarrete; Clelia Vallebuono
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  26     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-01     Completed Date:  2007-03-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  41-5     Citation Subset:  IM    
Affiliation:
Microbiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile. moryan@med.uchile.cl
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MeSH Terms
Descriptor/Qualifier:
Ambulatory Care Facilities / utilization*
Child, Preschool
Chile / epidemiology
Female
Humans
Infant
Male
Population Surveillance / methods
Prospective Studies
Rotavirus / isolation & purification*
Rotavirus Infections / epidemiology*
Serotyping / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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