| Impact of rituximab on stem cell mobilization following ACVBP regimen in poor-risk patients with diffuse large B-cell lymphoma: results from a large cohort of patients. | |
| | |
MedLine Citation:
|
PMID: 22563760 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: The ACVBP regimen is an efficient induction regimen for poor-risk patients with diffuse large B-cell lymphoma (DLBCL) before consolidative autologous stem cell transplantation. Adjunction of the monoclonal anti-CD20 antibody rituximab (R-ACVBP) was recently found to be superior to ACVBP alone. This study assessed the impact of rituximab on stem cell mobilization in two similar consecutive groups of patients treated with ACVBP in two prospective, controlled trials. STUDY DESIGN AND METHODS: The first trial (LNH-98B-3) involved 137 patients treated with ACVBP alone. In the second trial (LNH-03-3B), 91 patients received an R-ACVBP regimen. Stem cell mobilization was performed after a course of (R)-ACVBP. RESULTS: The median peak numbers of blood CD34+ cell counts recorded before the first apheresis procedure in the ACVBP and R-ACVBP groups were 69 × 10(6) and 63 × 10(6) /L, respectively (p = 0.55). The median numbers of CD34+ cells collected were 7.1 × 10(6) and 6.0 × 10(6) CD34+ cells/kg for the ACVBP and R-ACVBP groups, respectively (p = 0.13). The median number of apheresis procedures required for gathering the minimum amount of CD34+ cells (2 × 10(6) /kg) was the same in the two groups. CONCLUSION: When compared with ACVBP alone, adjunction of rituximab does not impair stem cell mobilization. |
| | |
Authors:
|
François Lefrère; Dominique Bastit-Barrau; Olivier Hequet; Philippe Bourin; Suzanne Mathieu-Nafissi; Alain Bohbot; Hervé Tilly; Gilles Salles; Christophe Fermé; Valérie Lapierre; Luc Fornecker; Jean-Michel Micléa; Loic Isebaert; Serge Bologna; Olivier Fitoussi; Nicolas Mounier; Corinne Haioun |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-5-7 |
Journal Detail:
|
Title: Transfusion Volume: - ISSN: 1537-2995 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
|
Created Date: 2012-5-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0417360 Medline TA: Transfusion Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 American Association of Blood Banks. |
Affiliation:
|
From the Département de Biothérapie, Hôpital Necker, AP-HP, Paris, France; the Etablissement Français du Sang, Région Normandie, France; the Etablissement Français du Sang, Région Rhône-Alpes, France; the Etablissement Français du Sang, Région Pyrénées-Méditerranée, France; the Etablissement Français du Sang, Lorraine-Champagne, France; the Service d'Hématologie, CHU, Strasbourg, France; the Service d'Hématologie, Centre Henri Becquerel, Rouen, France; the Service d'Hématologie, CHU Lyon Sud, Lyon, France; the Département de Médecine and the Centre de Thérapie Cellulaire, Institut de Cancérologie Gustave Roussy, Villejuif, France; the Service d'Hématologie Oncologie and Unité de Thérapie Cellulaire, Hôpital Saint-Louis, AP-HP, Paris, France; the Service d'Hématologie, Hôpital Purpan, CHU Toulouse, France; the Service d'Hématologie, Hôpital Brabois, CHU Nancy, France; the Service d'Hématologie, Polyclinique Bordeaux Nord, France; the Service d'Onco-Hématologie, Hôpital l'Archet, CHU Nice, France; and the Unité Hémopathies Lymphoïdes, Hôpital Henri-Mondor, Université Paris Est Créteil, Créteil, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Rye chromosome-specific polymerase chain reaction products developed by primers designed from the Ec...
Next Document: Cohesin controls planar cell polarity by regulating the level of the seven-pass transmembrane cadher...