Document Detail

Impact and risk factors for early-onset group B streptococcal morbidity: analysis of a national, population-based cohort in Sweden 1997-2001.
MedLine Citation:
PMID:  17083655     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To study early-onset group B streptococcal (EOGBS) morbidity, mortality, and maternal risk factors.
DESIGN: Observational, population-based, retrospective. Data from national registers and medical records.
SETTING: Sweden, 1997-2001.
POPULATION: Cohort of 640 infants with a diagnosis of GBS infection out of 435 070 live births.
METHOD: Infants with diagnoses GBS sepsis (P36.0) and/or pneumonia (P23.3) were analysed. In cases with P36.0, register data were validated against infant and maternal medical records. Odds ratios (OR) were estimated by multiple logistic regression.
MAIN OUTCOME MEASURES: Incidence of EOGBS morbidity, mortality, frequency of maternal risk factors and administration of intrapartum antibiotics.
RESULTS: There were 319 cases with EOGBS sepsis. Blood culture verified 174 cases. There were 145 with clinical sepsis and 180 with pneumonia only. The incidences were 0.40, 0.33, and 0.41 per 1000 live births, respectively. The mortality was 7.5, 0.7, and 2.2% in respective groups. The frequencies of established maternal risk factors were: membrane rupture > or =18 hours, 44%; prematurity, 26%; temperature during labour > or =38 degrees C, 22%. Novel maternal risk factors identified in verified cases were gestational age (GA) of 37 completed weeks (OR 3.5, 1.8-6.5) and gestational diabetes (OR 3.7, 1.8-8.5). When including clinical sepsis, also epidural anaesthesia, infant large for GA, postmaturity, and high maternal age were significant risk factors.
CONCLUSION: The incidence of verified EOGBS disease was 0.4 per 1000 live births with a total burden of EOGBS morbidity approximately three times higher. GA of 37 completed weeks and gestational diabetes were identified as additional significant risk factors.
S Håkansson; K Källén
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  113     ISSN:  1470-0328     ISO Abbreviation:  BJOG     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-26     Completed Date:  2007-01-26     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  1452-8     Citation Subset:  AIM; IM    
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MeSH Terms
Antibiotic Prophylaxis
Cohort Studies
Infant, Newborn
Infectious Disease Transmission, Vertical / prevention & control*
Pregnancy Complications, Infectious / epidemiology*
Prenatal Care
Retrospective Studies
Risk Factors
Sepsis / epidemiology
Streptococcal Infections / epidemiology,  prevention & control,  transmission*
Sweden / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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