| Impact of a risk-based prevention policy on neonatal group B streptococcal disease. | |
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MedLine Citation:
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PMID: 9855598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Neonatal group B streptococcal infections can be prevented by intrapartum antibiotic prophylaxis. Beginning in 1992, women with obstetric risk factors at University of Miami-Jackson Memorial Medical Center were targeted to receive intrapartum antibiotic prophylaxis. We evaluated these preventive efforts. STUDY DESIGN: A case was defined as isolation of group B streptococci from a sterile site in an infant <7 days old born during the study period, 1992-1995. We reviewed systematic samples of women with preterm delivery and prolonged rupture of membranes to assess use of intrapartum antibiotic prophylaxis. RESULTS: Group B streptococcal cases declined from 1.7 cases/1000 live births to 0.2 cases/1000 live births (Poisson regression, P =.002). Intrapartum antibiotic prophylaxis use increased from 13% of preterm deliveries in 1992 to 42% in 1995, and from 20% of deliveries with prolonged rupture of membranes in 1992 to 72% in 1995 (chi2 test for linear trend P =.007 and P <.001, respectively). CONCLUSION: Provision of intrapartum antibiotic prophylaxis on the basis of risk factors was associated with decreased group B streptococcal disease. |
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Authors:
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S H Factor; O S Levine; A Nassar; J Potter; A Fajardo; M J O'Sullivan; A Schuchat |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 179 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-01-15 Completed Date: 1999-01-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1568-71 Citation Subset: AIM; IM |
Affiliation:
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Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, University of Miami-Jackson Memorial Medical Center, Miami, Florida, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibiotic Prophylaxis* Chi-Square Distribution Female Fetal Membranes, Premature Rupture Humans Incidence Infant, Newborn Infant, Premature Poisson Distribution Pregnancy Pregnancy Complications, Infectious / drug therapy Retrospective Studies Risk Factors Streptococcal Infections / epidemiology, ethnology, prevention & control* Streptococcus agalactiae* / isolation & purification |
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