Document Detail

Impact of a risk-based prevention policy on neonatal group B streptococcal disease.
MedLine Citation:
PMID:  9855598     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Neonatal group B streptococcal infections can be prevented by intrapartum antibiotic prophylaxis. Beginning in 1992, women with obstetric risk factors at University of Miami-Jackson Memorial Medical Center were targeted to receive intrapartum antibiotic prophylaxis. We evaluated these preventive efforts. STUDY DESIGN: A case was defined as isolation of group B streptococci from a sterile site in an infant <7 days old born during the study period, 1992-1995. We reviewed systematic samples of women with preterm delivery and prolonged rupture of membranes to assess use of intrapartum antibiotic prophylaxis. RESULTS: Group B streptococcal cases declined from 1.7 cases/1000 live births to 0.2 cases/1000 live births (Poisson regression, P =.002). Intrapartum antibiotic prophylaxis use increased from 13% of preterm deliveries in 1992 to 42% in 1995, and from 20% of deliveries with prolonged rupture of membranes in 1992 to 72% in 1995 (chi2 test for linear trend P =.007 and P <.001, respectively). CONCLUSION: Provision of intrapartum antibiotic prophylaxis on the basis of risk factors was associated with decreased group B streptococcal disease.
S H Factor; O S Levine; A Nassar; J Potter; A Fajardo; M J O'Sullivan; A Schuchat
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  179     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-01-15     Completed Date:  1999-01-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1568-71     Citation Subset:  AIM; IM    
Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, University of Miami-Jackson Memorial Medical Center, Miami, Florida, USA.
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MeSH Terms
Antibiotic Prophylaxis*
Chi-Square Distribution
Fetal Membranes, Premature Rupture
Infant, Newborn
Infant, Premature
Poisson Distribution
Pregnancy Complications, Infectious / drug therapy
Retrospective Studies
Risk Factors
Streptococcal Infections / epidemiology,  ethnology,  prevention & control*
Streptococcus agalactiae* / isolation & purification

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