| Impact of retinol binding protein 4 polymorphism on rosiglitazone response in Chinese Type 2 diabetic patients. | |
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MedLine Citation:
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PMID: 22086013 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective To explore the association between rs3758539G-803A and rs10882283T-179G polymorphism of retinol binding protein 4 (RBP4) and rosiglitazone response in Chinese type 2 diabetes mellitus (T2DM) patients. Methods A total of 472 Chinese T2DM patients and 198 healthy subjects were enrolled to identify G-803A and T-179G genotypes using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Forty-two T2DM patients with different G-803A or T-179G genotypes were selected to undergo a 12-week rosiglitazone treatment (4 mg/d). Serum fasting plasma glucose (FPG),postprandial plasma glucose (PPG),fasting serum insulin (FINS),glycated hemoglobin (HbAlc),postprandial serum insulin (PINS),triglyceride (TG),low-density lipoprotein-cholesterol (LDL-c),and high-density lipoprotein-cholesterol (HDL-c) were determined before and after the rosiglitazone treatment. Results T2DM patients with RBP4 G-803A GG genotype showed lower TG and LDL-c concentrations compared with that in the GA+AA genotype subjects. T2DM patients with RBP4 T-179G TT genotype showed lower waist-to-hip ratio (WHR),FPG and FINS values compared with that in the TG+GG genotype individuals. Patients with GG genotype of RBP4 G-803A had an enhanced rosiglitazone efficacy on FPG and FINS compared with that in the GA+AA genotype group. Patients with RBP4 T-179G TG+GG genotype showed an enhanced rosiglitazone efficacy on HbAlc level compared with that in the TT genotype group. Conclusion RBP4 G-803A and T-179G polymorphism might be associated with the development of T2DM and affect the therapeutic efficacy of rosignitazone in Chinese T2DM patients. |
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Authors:
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Fang Zhou; Qiong Huang; Xingping Dai; Jiye Yin; Jing Wu; Honghao Zhou; Zhicheng Gong; Zhaoqian Liu |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences Volume: 36 ISSN: 1672-7347 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101230586 Medline TA: Zhong Nan Da Xue Xue Bao Yi Xue Ban Country: - |
Other Details:
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Languages: ENG Pagination: 949-957 Citation Subset: - |
Affiliation:
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Institute of Clinical Pharmacology,Hunan Key Laboratory of Pharmacogenetics,Central South University, Changsha 410078; Department of Biomedical,Yueyang Vocational and Technical College, Yueyang Hunan 414000,China. |
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