| Impact of resistance to thyroid hormone on the cardiovascular system in adults. | |
| | |
MedLine Citation:
|
PMID: 19435825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The clinical manifestations of resistance to thyroid hormone (RTH) are highly variable, and the impact of RTH on the cardiovascular system has been poorly investigated. AIM: The objective of the study was to evaluate the cardiovascular characteristics of 16 untreated and asymptomatic patients with RTH compared with 16 euthyroid healthy controls to define the cardiovascular involvement in RTH syndrome. PATIENTS AND METHODS: Sixteen untreated and asymptomatic RTH patients (eight males; aged 33 +/- 12 yr, range 21-45 yr) and 16 controls (nine males; aged 33 +/- 5 yr, range 24-42 yr) were enrolled. Clinical data, thyroid status, and echocardiographic results were recorded. RESULTS: Heart rate was comparable with that of controls, whereas arterial pressure was higher than controls. Mean interventricular septum diastolic thickness and mean left ventricular (LV) posterior wall diastolic thickness were significantly lower in RTH patients than controls with a consequent significant decrease of the mean LV mass and LV mass indexed by body surface area. Patients also had abnormalities of myocardial relaxation as indicated by a significant increase of peak A and consequent reduction of the early to late ratio. Finally, systemic vascular resistance was significantly higher in RTH patients than controls. CONCLUSIONS: Our results suggest the presence of cardiovascular alterations in asymptomatic and untreated RTH patients similar to those reported in hypothyroid patients. Our strict selection likely created a bias in the inclusion of a particular type of RTH patients, who could represent a minority of patients with RTH. However, no correlation was found between the type of mutation and cardiovascular characteristics of RTH patients. |
| | |
Authors:
|
Melania Pulcrano; Emiliano Antonio Palmieri; Deborah Mannavola; Michele Ciulla; Irene Campi; Danila Covelli; Gaetano Lombardi; Bernadette Biondi; Paolo Beck-Peccoz |
Related Documents
:
|
20362415 - Non sustained ventricular tachycardia in hypertrophic cardiomyopathy and new ultrasonic... 2188985 - Early ambulation after 5 french diagnostic cardiac catheterization: results of a multic... 20838715 - Assessment of right ventricular systolic function using tricuspid annular-plane systoli... 20691835 - Correlation of heart-type fatty acid-binding protein with mortality and echocardiograph... 22492095 - Sympathetic nerve activity in stress-induced cardiomyopathy. 12203075 - Color doppler findings of gastric varices compared with findings on computed tomography. |
Publication Detail:
|
Type: Journal Article Date: 2009-05-12 |
Journal Detail:
|
Title: The Journal of clinical endocrinology and metabolism Volume: 94 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2009 Aug |
Date Detail:
|
Created Date: 2009-08-06 Completed Date: 2009-08-25 Revised Date: 2009-09-18 |
Medline Journal Info:
|
Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 2812-6 Citation Subset: AIM; IM |
Affiliation:
|
Department of Clinical and Molecular Endocrinology and Oncology, University Federico II of Naples, Via S. Pansini 5, Naples, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Pressure* Female Heart Rate* Humans Male Middle Aged Thyroid Hormone Resistance Syndrome / physiopathology* Ventricular Function, Left |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Differential islet and incretin hormone responses in morning versus afternoon after standardized mea...
Next Document: Variations in infant feeding practice are associated with body composition in childhood: a prospecti...