Document Detail

Impact of reduced daily physical activity on conduit artery flow-mediated dilation and circulating endothelial microparticles.
MedLine Citation:
PMID:  24072406     Owner:  NLM     Status:  MEDLINE    
Physical inactivity promotes the development of cardiovascular diseases. However, few data exist examining the vascular consequences of short-term reductions in daily physical activity. Thus we tested the hypothesis that popliteal and brachial artery flow-mediated dilation (FMD) would be reduced and concentrations of endothelial microparticles (EMPs) would be elevated following reduced daily physical activity. To examine this, popliteal and brachial artery FMD and plasma levels of EMPs suggestive of apoptotic and activated endothelial cells (CD31(+)/CD42b(-) and CD62E(+) EMPs, respectively) were measured at baseline and during days 1, 3, and 5 of reduced daily physical activity in 11 recreationally active men (25 ± 2 yr). Subjects were instructed to reduce daily physical activity by taking <5,000 steps/day and refraining from planned exercise. Popliteal artery FMD decreased with reduced activity (baseline: 4.7 ± 0.98%, reduced activity day 5: 1.72 ± 0.68%, P < 0.05), whereas brachial artery FMD was unchanged. In contrast, baseline (pre-FMD) popliteal artery diameter did not change, whereas brachial artery diameter decreased (baseline: 4.35 ± 0.12, reduced activity day 5: 4.12 ± 0.11 P < 0.05) following 5 days of reduced daily physical activity. CD31(+)/CD42b(-) EMPs were significantly elevated with reduced activity (baseline: 17.6 ± 9.4, reduced activity day 5: 104.1 ± 43.1 per μl plasma, P < 0.05), whereas CD62E(+) EMPs were unaltered. Collectively, our results provide evidence for the early and robust deleterious impact of reduced daily activity on vascular function and highlight the vulnerability of the vasculature to a sedentary lifestyle.
Leryn J Boyle; Daniel P Credeur; Nathan T Jenkins; Jaume Padilla; Heather J Leidy; John P Thyfault; Paul J Fadel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-09-26
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  115     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-18     Completed Date:  2014-07-16     Revised Date:  2014-11-15    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1519-25     Citation Subset:  IM    
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MeSH Terms
Antigens, CD31 / blood
Biological Markers / blood
Blood Flow Velocity
Brachial Artery / physiopathology*,  ultrasonography
Cell-Derived Microparticles / metabolism*,  pathology
E-Selectin / blood
Endothelial Cells / metabolism*,  pathology
Hyperemia / physiopathology
Platelet Glycoprotein GPIb-IX Complex / metabolism
Popliteal Artery / physiopathology*,  ultrasonography
Regional Blood Flow
Risk Factors
Sedentary Lifestyle*
Time Factors
Ultrasonography, Doppler
Young Adult
Grant Support
Reg. No./Substance:
0/Antigens, CD31; 0/Biological Markers; 0/E-Selectin; 0/Platelet Glycoprotein GPIb-IX Complex; 0/SELE protein, human

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