Document Detail


Impact of radiotherapy on fertility, pregnancy, and neonatal outcomes in female cancer patients.
MedLine Citation:
PMID:  19306747     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Radiation has many potential long-term effects on cancer survivors. Female cancer patients may experience decreased fertility depending on the site irradiated. Oncologists should be aware of these consequences and discuss options for fertility preservation before initiating therapy.
METHODS AND MATERIALS: A comprehensive review of the existing literature was conducted. Studies reporting the outcomes for female patients treated with cranio-spinal, abdominal, or pelvic radiation reporting fertility, pregnancy, or neonatal-related outcomes were reviewed.
RESULTS: Cranio-spinal irradiation elicited significant hormonal changes in women that affected their ability to become pregnant later in life. Women treated with abdomino-pelvic radiation have an increased rate of uterine dysfunction leading to miscarriage, preterm labor, low birth weight, and placental abnormalities. Early menopause results from low-dose ovarian radiation. Ovarian transposition may decrease the rates of ovarian dysfunction.
CONCLUSIONS: There is a dose-dependent relationship between ovarian radiation therapy (RT) and premature menopause. Patients treated with RT must be aware of the impact of treatment on fertility and explore appropriate options.
Authors:
Jennifer Y Wo; Akila N Viswanathan
Related Documents :
22683027 - Fertility after ovarian follicular wave synchronization and fixed-time natural mating c...
23337047 - Personal and family attributes of pregnant teenagers: findings from a community-based s...
18097327 - Gasless laparoscopic surgery for ovarian cyst in a second trimester pregnant patient wi...
22549707 - Consequences of superovulation and art procedures.
14535267 - Pathology, danger, and power: women's and physicians' views of pregnancy and childbirth...
16895747 - Ultra-structural changes and developmental potential of porcine oocytes following vitri...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  73     ISSN:  1879-355X     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-24     Completed Date:  2009-04-03     Revised Date:  2011-09-26    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1304-12     Citation Subset:  IM    
Affiliation:
Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA 02115, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / etiology
Age Factors
Brain Neoplasms / radiotherapy
Cranial Irradiation / adverse effects
Dose-Response Relationship, Radiation
Female
Fertility / radiation effects*
Humans
Hypothalamo-Hypophyseal System / radiation effects
Infant, Newborn
Infertility, Female / etiology*,  prevention & control*
Ovary / radiation effects
Pregnancy
Primary Ovarian Insufficiency / etiology
Radiotherapy / adverse effects*
Survivors
Uterus / radiation effects
Grant Support
ID/Acronym/Agency:
K07 CA117979-01/CA/NCI NIH HHS; K07 CA117979-02/CA/NCI NIH HHS; K07 CA117979-03/CA/NCI NIH HHS; K07 CA117979-04/CA/NCI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Larynx preservation clinical trial design: key issues and recommendations-a consensus panel summary.
Next Document:  Does incidental irradiation with doses below 50 gy effectively reduce isolated nodal failures in non...