Document Detail

Impact of radiotherapy on fertility, pregnancy, and neonatal outcomes in female cancer patients.
MedLine Citation:
PMID:  19306747     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Radiation has many potential long-term effects on cancer survivors. Female cancer patients may experience decreased fertility depending on the site irradiated. Oncologists should be aware of these consequences and discuss options for fertility preservation before initiating therapy.
METHODS AND MATERIALS: A comprehensive review of the existing literature was conducted. Studies reporting the outcomes for female patients treated with cranio-spinal, abdominal, or pelvic radiation reporting fertility, pregnancy, or neonatal-related outcomes were reviewed.
RESULTS: Cranio-spinal irradiation elicited significant hormonal changes in women that affected their ability to become pregnant later in life. Women treated with abdomino-pelvic radiation have an increased rate of uterine dysfunction leading to miscarriage, preterm labor, low birth weight, and placental abnormalities. Early menopause results from low-dose ovarian radiation. Ovarian transposition may decrease the rates of ovarian dysfunction.
CONCLUSIONS: There is a dose-dependent relationship between ovarian radiation therapy (RT) and premature menopause. Patients treated with RT must be aware of the impact of treatment on fertility and explore appropriate options.
Jennifer Y Wo; Akila N Viswanathan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  73     ISSN:  1879-355X     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-24     Completed Date:  2009-04-03     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1304-12     Citation Subset:  IM    
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MeSH Terms
Abortion, Spontaneous / etiology
Age Factors
Brain Neoplasms / radiotherapy
Cranial Irradiation / adverse effects
Dose-Response Relationship, Radiation
Fertility / radiation effects*
Hypothalamo-Hypophyseal System / radiation effects
Infant, Newborn
Infertility, Female / etiology*,  prevention & control*
Ovary / radiation effects
Primary Ovarian Insufficiency / etiology
Radiotherapy / adverse effects*
Uterus / radiation effects
Grant Support
K07 CA117979/CA/NCI NIH HHS; K07 CA117979-01/CA/NCI NIH HHS; K07 CA117979-02/CA/NCI NIH HHS; K07 CA117979-03/CA/NCI NIH HHS; K07 CA117979-04/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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