Document Detail

Impact of pulmonary hypertension on gas exchange and exercise capacity in patients with pulmonary fibrosis.
MedLine Citation:
PMID:  18804360     Owner:  NLM     Status:  MEDLINE    
Pulmonary hypertension is a relevant interceding morbidity in patients with pulmonary fibrosis that has significant impact on exercise tolerance and outcome. The aim of this study was to further characterize the exercise intolerance, dyspnoea and ventilatory inefficiency of patients with pulmonary fibrosis in the presence or absence of pulmonary hypertension via cardiopulmonary exercise testing. Thirty-four patients underwent pulmonary function testing, symptom-limited exercise testing on a bicycle and dyspnoea evaluation according to the BORG scale. Pulmonary hypertension was assessed by echocardiography and in a subset of patient's right heart catheterization. Sixteen of 34 patients with pulmonary fibrosis revealed pulmonary hypertension. While all study patients did not differ in lung functions and demographic characteristics, patients suffering from pulmonary hypertension showed a significantly impaired exercise tolerance and worsened ventilatory inefficiency. The extent of pulmonary artery pressure elevation impacted significantly on ventilatory inefficiency. In addition, the increased ventilatory requirements significantly influenced the extent of dyspnoea in patients with pulmonary hypertension. We conclude that pulmonary hypertension has a significant impact on exercise capacity and dyspnoea in patients with interstitial lung disease (ILD). The further impairment of exercise capacity as well as the extent of dyspnoea in patients with interceding PHT is attributable to a significantly impaired ventilatory inefficiency.
Sven Gläser; Oliver Noga; Beate Koch; Christian F Opitz; Bernd Schmidt; Bettina Temmesfeld; Marcus Dörr; Ralf Ewert; Christoph Schäper
Publication Detail:
Type:  Journal Article     Date:  2008-09-18
Journal Detail:
Title:  Respiratory medicine     Volume:  103     ISSN:  1532-3064     ISO Abbreviation:  Respir Med     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-23     Completed Date:  2009-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  317-24     Citation Subset:  IM    
Division of Pulmonary Medicine and Infectious Diseases, University of Greifswald, Sauerbruchstrasse, 17475 Greifswald, Germany.
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MeSH Terms
Aged, 80 and over
Dyspnea / physiopathology*,  ultrasonography
Exercise Test
Exercise Tolerance / physiology
Hemodynamics / physiology
Hypertension, Pulmonary / physiopathology*,  ultrasonography
Lung / physiopathology*,  ultrasonography
Middle Aged
Pulmonary Fibrosis / physiopathology*,  ultrasonography
Pulmonary Gas Exchange / physiology*

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