Document Detail


Impact of public health strategies on the birth prevalence of cystic fibrosis in Brittany, France.
MedLine Citation:
PMID:  12768409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Taking into account the situation of Brittany, a region of western France where cystic fibrosis (CF) is common and where a neonatal screening program was set up 14 years ago, the aim of this study was to determine the way in which the birth prevalence of CF has been influenced by the various public health strategies implemented in the region (neonatal screening, prenatal diagnosis, ultrasound examination and family testing). This study used the results of the neonatal screening program, which enabled a precise measure of the prevalence of CF at birth to be obtained. Over the same period, we collected data from prenatal diagnoses carried out in the region, first in families related to a CF child and also those made following the detection of an echogenic bowel upon routine ultrasound examination performed during pregnancy. The prevalence of CF at birth was estimated to be 1/2838 in the region over a 10-year period (1992-2001). By including the 54 CF-affected pregnancies that were terminated during these 10 years, the corrected birth prevalence of CF was 1/1972. Prenatal diagnosis was therefore responsible for a global decrease in CF prevalence at birth of 30.5%. This work constitutes the first study able to provide a precise measure of CF birth prevalence and of its evolution through the combined effects of neonatal screening, prenatal diagnosis, ultrasound examination and family testing.
Authors:
Virginie Scotet; Marie-Pierre Audrézet; Michel Roussey; Gilles Rault; Martine Blayau; Marc De Braekeleer; Claude Férec
Related Documents :
2333699 - Meckel-gruber syndrome. a lethal combination of abnormalities.
16104669 - Second trimester serum markers.
18760229 - Prenatal diagnosis and genetic screening--integration into prenatal care.
10419619 - Maternal serum prostate-specific antigen and down syndrome in the first and second trim...
17702049 - Dehydrosteroid measurements in maternal urine or serum for the prenatal diagnosis of sm...
7694429 - Maternal serum screening for neural tube defects and fetal chromosome abnormalities.
3817269 - Pregnancy outcome in women perceiving decreased fetal movement.
8990429 - One- versus two-layer closure of a low transverse cesarean: the next pregnancy.
11679519 - Vitrification of mouse oocytes using closed pulled straws (cps) achieves a high surviva...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-05-27
Journal Detail:
Title:  Human genetics     Volume:  113     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-28     Completed Date:  2003-08-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  280-5     Citation Subset:  IM    
Affiliation:
INSERM EMI 01-15, Laboratoire de Génétique Moléculaire et d'Histocompatibilité, Hospital, University, EFS-Bretagne, 46 Rue Félix Le Dantec, BP 454, 29275, Brest Cédex, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cystic Fibrosis / diagnosis,  epidemiology*,  genetics,  prevention & control*
Cystic Fibrosis Transmembrane Conductance Regulator / genetics*
Female
France / epidemiology
Genetic Testing
Humans
Infant, Newborn
Male
Molecular Epidemiology*
Neonatal Screening
Prenatal Diagnosis
Prevalence
Public Health* / methods
Ultrasonography, Prenatal
Chemical
Reg. No./Substance:
0/CFTR protein, human; 126880-72-6/Cystic Fibrosis Transmembrane Conductance Regulator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Distribution and chemical coding of cocaine- and amphetamine-regulated transcript peptide (CART)-imm...
Next Document:  Comparison of the utility of barley retrotransposon families for genetic analysis by molecular marke...